Principles of Asymmetric Synthesis: Forew. by Dieter Seebach - Softcover

Gawley, Robert E.; Aube, Jeffrey

Softcover

ISBN 10: 0080448607 ISBN 13: 9780080448602

Verlag: Elsevier, 2012

Inhaltsangabe

The world is chiral. Most of the molecules in it are chiral, and asymmetric synthesis is an important means by which enantiopure chiral molecules may be obtained for study and sale. Using examples from the literature of asymmetric synthesis, this book presents a detailed analysis of the factors that govern stereoselectivity in organic reactions.

After an explanation of the basic physical-organic principles governing stereoselective reactions, the authors provide a detailed, annotated glossary of stereochemical terms. A chapter on "Practical Aspects of Asymmetric Synthesis" provides a critical overview of the most common methods for the preparation of enantiomerically pure compounds, techniques for analysis of stereoisomers using chromatographic, spectroscopic, and chiroptical methods.

The authors then present an overview of the most important methods in contemporary asymmetric synthesis organized by reaction type. Thus, there are four chapters on carbon-carbon bond forming reactions, one chapter on reductions, and one on oxidations (carbon-oxygen and carbon-nitrogen bond forming reactions). This organization allows the reader to compare the leading methods for asymmetric synthesis in an appropriate context.

A highlight of the book is the presentation and discussion of transition states at the current level of understanding, for important reaction types. In addition, extensive tables of examples are used to give the reader an appreciation for the scope of each reaction. Finally, leading references are provided to natural product synthesis that has been accomplished using a given reaction as a key step.

Über diesen Titel

Über die Autorin bzw. den Autor

Department of Medicinal Chemistry, University of North Carolina, USA

Details zur Ausgabe

• Verlag: Elsevier
• Erscheinungsdatum: 2012
• Sprache: Englisch
• ISBN 10: 0080448607
• ISBN 13: 9780080448602
• Einband: Taschenbuch
• Auflage: 2
• Anzahl der Seiten: 568
• Kontakt zum Hersteller: Nicht verfügbar
• Verantwortliche Person: Barbara Criscuolo; b.criscuolo@lswr.it; ; Via Spadolini, 7; Milano; 20141; Italien