Advances in Cancer Research provides invaluable information on the exciting and fast-moving field of cancer research. Here once again, outstanding and original reviews are presented.
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This latest volume in Advances in Cancer Research once again proves to be a first-rate source of the best research in the field. Volume 78 contains five comprehensive reviews, beginning with Zwerschke and Jansen-Durr summarizing the available data on the interaction of E7 with cellular regulatory factors and the functional consequences of these interactions. In Chapter 2, Alan Wells focuses on the emerging understanding of the biochemical and biophysical foundations of growth factor-induced cell motility and tumor cell invasiveness and the implications for development of targeted agents, with particular emphasis on signaling from the EGF and HGF receptors, as these have most often been associated with tumor invasion. Chapter 3, by Mignatti and Rifkin, discusses the structure of ECM-degrading proteinases and their interactions with cell membrane and ECM components. Murakami-Mori, Mori, and Bonavida address the issues of and outline recent advances in the molecular pathogenesis of Kaposi's sarcoma. Using cultured KS tumor cells, they have studied intracellular molecular events underlying the growth and apoptosis of these cells. Finally, Kelloff provides an overview of the progress in the field of chemoprevention and concludes with a discussion of the major issues and challenges of chemoprevention drug development and the tremendous opportunity it promises for reduction of cancer in humans.
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