Assimilates the contributions of genome organization and the nuclear matrix to the control of DNA and RNA synthesis, discussing theoretical and experimental approaches that define functionality of nuclear morphology. Contains sections on the history and definition of the nuclear matrix and its structure and function, chromatin structure and transcription complexes, and nuclear mRNP complexes, highlighting areas such as nuclear structure in gene localization, aberrations in nuclear architecture, and how nuclear structure exerts a regulatory effect on other aspects of cell function/physiology. Annotation c. by Book News, Inc., Portland, Or.
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Wilfred Stein is the author of three previous books on membrane transport, the first appearing almost fifty years ago. He has edited numerous books and written some 180 papers on various aspects of membrane transport and especially transport kinetics. These papers, especially those written together with his colleague William Lieb, defined many of the concepts used today in discussing movement across cell membranes. More recently he has turned to the study of the kinetics of drugs used in cancer therapy and in the treatment of malaria. He has taught biochemistry, biophysics and physiology at the University of Manchester and the Hebrew University of Jerusalem and also at the Weizmann Institute in Israel. He is currently Emeritus Professor of Biophysics at the Hebrew University. He is married to a librarian and has four children and nine grandchildren.
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