The Organic Chemistry of Enzyme-catalyzed Reactions - Hardcover

Silverman, Richard-B

Hardcover

ISBN 10: 0126437459 ISBN 13: 9780126437454

Verlag: Academic press, 1999

Inhaltsangabe

Book by Silverman PhD Organic Chemistry Richard B

Über diesen Titel

Críticas:

"Whether you are teaching, learning, or trying to inhibit an enzyme, you will find this book invaluable."--JOURNAL OF MEDICINAL CHEMISTRY, 2000, Vol. 43, No 13"Silverman's newest contribution will serve as an outstanding text and reference on the reaction mechanisms of enzymes. ...it may easily serve as the foundation for an advanced course on contemporary topics of substrate recognition, activation, and catalytic turnover. His treatment of the topic should also appeal to a broad range of organic, medicinal, and biological chemists who desire an up-to-date and succinct overview of the field. Silverman should be congratulated for publishing yet another book of high quality and significance. This newest contribution to enzymology should quickly become the standard for mechanistic studies. Ample figures and schemes enliven each section, and all aspects fo teh text have been composed with great precision. Silverman simultaneously elucidates both the experimental approaches and results that constitute much of enzymology."--Steven Rokita, University of Maryland; JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, June 14, 2000, Vol. 122, No. 33."Successfully highlights some of the most sophisticated advances of the past decade while still covering the basic tenets of enzymology. Silverman should be congratulated for publishing yet another book of high quality and significance. The newest contribution to enzymology should quicly become the standard for mechanistic studies. Ample figures and schemes enliven each section, and all aspects of the text have beeen composed with great precision. Silverman simultaneously elucidates both the experimental approaches and the results that constitutemuch of enzymology."--JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, June 14, 2000, Vol. 122, No. 33.

Reseña del editor:

Written for advanced undergraduate and graduate students as well as professionals in organic and medicinal chemistry and biochemistry, this unique text illuminates the "black box" of enzyme-catalyzed reactions by showing how enzymes are simply highly efficient organic chemists. Enzyme-catalyzed reactions are essential for the design of enzyme inhibitors in the pharmaceutical and agricultural industries, and of growing importance for process development in the chemical and biotechnology industries. Following a general introduction to the role of enzymes as catalysts, each chapter describes the organic reaction mechanisms that are used by enzymes to catalyze a particular family of organic transformations. The compilation includes a vast number of drawings to illustrate structures and mechanisms, and focuses on one or two examples of enzymes that catalyze the particular chemistry for that transformation. The Organic Chemistry of Enzyme-Catalyzed Reactions is not a book on enzymes, but rather the general mechanisms used by enzymes. Extensive references refer to the many experiments that have helped to elucidate enzyme mechanisms. Chemical model studies as an aid in mechanistic studies are also discussed, as are the design of haptens and the generation of catalytic antibodies ("designer enzymes"). Problem sets and solutions are provided to check the reader's understanding of the principles described.

Über diese Auflage

• Verlag: Academic press
• Erscheinungsdatum: 1999
• ISBN 10: 0126437459
• ISBN 13: 9780126437454
• Einband: Tapa dura
• Anzahl der Seiten: 534