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Enzymes of Epigenetics (Volume 573) (Methods in Enzymology, Volume 573, Band 573) - Hardcover

Buch 207 von 272: ISSN
 
9780128053652: Enzymes of Epigenetics (Volume 573) (Methods in Enzymology, Volume 573, Band 573)
Hardcover
ISBN 10: 0128053658 ISBN 13: 9780128053652
Verlag: Academic Press, 2016

Inhaltsangabe

Enzymes of Epigenetics, one of two new volumes in the Methods in Enzymology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field.

This volume covers research methods that are employed to study epigenetic regulation and includes structural, biochemical, molecular, biological, cellular, computational, and systems approaches.

Topics include chromatin structure and histones, posttranslational histone modification enzymes and complexes, histone modification binders, DNA modifications and nucleic acid regulators, epigenetic technologies and small molecule epigenetic regulators, and biological connections

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Über die Autorin bzw. den Autor

Dr. Marmorstein obtained his Ph.D. in Chemistry from the University of Chicago and, following a postdoctoral fellowship at Harvard University and a faculty appointment at The Wistar Institute, he joined the faculty at the Perelman School of Medicine at the University of Pennsylvania. Dr. Marmorstein is currently a Professor in the Department of Biochemistry and Biophysics and an Investigator in the Abramson Family Cancer Research Institute with adjunct appoints in the Department of Chemistry at the University of Pennsylvania and The Wistar Institute. The Marmorstein laboratory uses a broad range of molecular, biochemical and biophysical research tools centered on X-ray crystal structure determination to understand the chemical basis for the epigenetic regulation of gene expression. The laboratory is particularly interested in gene regulatory proteins and their upstream signaling kinases that are aberrantly regulated in cancer and other age-related disorders such as obesity and Alzheimer’s disease, and the use of high-throughput small molecule screening and structure-based design strategies towards the development of protein-specific small-molecule probes of protein function and for development into therapeutic agents.

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Verlag
Academic Press
Erscheinungsdatum
2016
Sprache
Englisch
ISBN 10 
0128053658
ISBN 13 
9780128053652
Einband
Gebundene Ausgabe
Anzahl der Seiten
528
Herausgeber
Marmorstein Ronen
Kontakt zum Hersteller
Academic Press
https://shop.elsevier.com/

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