The Epigenetics of Autoimmunity (Volume 5) (Translational Epigenetics, Volume 5, Band 5) - Hardcover

Hardcover

ISBN 10: 0128099127 ISBN 13: 9780128099124

Verlag: Academic Press, 2018

Inhaltsangabe

The Epigenetics of Autoimmunity covers a topic directly related to translational epigenetics. Via epigenetic mechanisms, a number of internal and external environmental risk factors, including smoking, nutrition, viral infection and the exposure to chemicals, could exert their influence on the pathogenesis of autoimmune diseases. Such factors could impact the epigenetic mechanisms, which, in turn, build relationship with the regulation of gene expression, and eventually triggering immunologic events that result in instability of immune system. Since epigenetic aberrations are known to play a key role in a long list of human diseases, the translational significance of autoimmunity epigenetics is very high.

To bridge the gap between environmental and genetic factors, over the past few years, great progress has been made in identifying detailed epigenetic mechanisms for autoimmune diseases. Furthermore, with rapid advances in technological development, high-throughput screening approaches and other novel technologies support the systematic investigations and facilitate the epigenetic identification. This book covers autoimmunity epigenetics from a disease-oriented perspective and several chapters are presented that provide advances in wide-spread disorders or diseases such as systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), multiple sclerosis (MS), type 1 diabetes (T1DM), systemic sclerosis (SSc), primary Sjögren's syndrome (pSS) and autoimmune thyroid diseases (AITDs).

These emerging epigenetic studies provide new insights into autoimmune diseases, raising great expectations among researchers and clinicians. This seminal book on this topic comprehensively covers the most recent advances in this exciting and rapidly developing new science. They might reveal not only new clinical biomarkers for diagnosis and disease progression, but also novel targets for potential epigenetic therapeutic treatment.

Über diesen Titel

Über die Autorin bzw. den Autor

Professor of Immunology at the Research Center of Basic Medical Sciences, at the Tianjin Medical University, Tianjin, China. He is editorial board member of the International Journal of Immunotherapy and Cancer Research.

Details zur Ausgabe

• Verlag: Academic Press
• Erscheinungsdatum: 2018
• Sprache: Englisch
• ISBN 10: 0128099127
• ISBN 13: 9780128099124
• Einband: Gebundene Ausgabe
• Anzahl der Seiten: 432
• Herausgeber: Zhang Rongxin
• Kontakt zum Hersteller: Elsevier Science & Technology; tradeorders@elsevier.com; ; London Wall 125; London; EC2Y 5AS; Vereinigtes Königreich
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