Physiologically Based Pharmacokinetic (PBPK) Modeling: Methods and Applications in Toxicology and Risk Assessment - Softcover

Softcover

ISBN 10: 0128185961 ISBN 13: 9780128185964

Verlag: Academic Press, 2020

Inhaltsangabe

Physiologically Based Pharmacokinetic (PBPK) Modeling: Methods and Applications in Toxicology and Risk Assessment presents foundational principles, advanced techniques and applications of PBPK modeling. Contributions from experts in PBPK modeling cover topics such as pharmacokinetic principles, classical physiological models, the application of physiological models for dose-response and risk assessment, the use of in vitro information, and in silico methods. With end-of-chapter exercises that allow readers to practice and learn the skills associated with PBPK modeling, dose-response, and its applications to safety and risk assessments, this book is a foundational resource that provides practical coverage of PBPK modeling for graduate students, academics, researchers, and more.

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Über die Autorinnen und Autoren

Dr. Jeffrey Fisher is a research toxicologist with the U.S. Food and Drug Administration, National Center for Toxicological Research. He was formerly a Professor in the Department of Environmental Health Science, College of Public Health at the University of Georgia (UGA). He joined the University of Georgia in 2000 and served as Department Head of the Department of Environmental Health Sciences from 2000 to 2006 and Director of the Interdisciplinary Toxicology Program at UGA from 2006-2010. He spent most of his career at the Toxicology Laboratory, Wright Patterson AFB, where he was Principal Investigator and Senior Scientist in the Toxics Hazards Division and Technical Advisor for the Operational Toxicology Branch. Dr. Fisher has published over 170 papers on pharmacokinetics and PBPK modeling in laboratory animals and humans. He has served on several national panels and advisory boards for the DoD, ATSDR, USEPA and non-profit organizations. He was a U.S. delegate for the North Atlantic Treaty Organization. Dr. Fisher served on the International Life Sciences Institute Steering Committee, which evaluated chloroform and dichloroacetic acid using EPA-proposed Carcinogen Risk Guidelines. He is Past President of the Biological Modeling Specialty Section of the Society of Toxicology, reviewer for several toxicology journals, and was Co-Principal Investigator on a National Institutes of Health (NIH)-supported workshop on Mathematical Modeling at the University of Georgia in the fall of 2003. He was a member of the National Academy of Sciences subcommittee on Acute Exposure Guideline Levels (AEGLs) from 2004-2010 and Science Advisory Board for the US EPA (2007-2010). He is a fellow of the Academy of Toxicological Sciences and an associate editor for Toxicological Sciences. Dr. Fisher has a B.S. degree in biology from the University of Nebraska at Kearney, a M.S. degree in biology from Wright State University, and a Ph.D. in Zoology/Toxicology from Miami University.

Dr. Jeffery M. Gearhart is a Senior Toxicologist with the Henry M. Jackson Foundation for Military Medicine, working in the United States Air Force School of Aerospace Medicine, Aeromedical Department, Wright-Patterson AFB. Dr. Gearhart also is an adjunct professor in the Department of Pharmacology and Toxicology, at the Boonshoft School of Medicine, Wright State University, Dayton, Ohio. He has been a Diplomat of the American Board of Toxicology (DABT) since 1991 and been actively involved in the Society of Toxicology since 1981, a full member since 1990, having served as president and counselor for the Biological Modeling Specialty Section, and counselor for the Inhalation and Respiratory Specialty Section. Dr. Gearhart received his B.S. in Biology from the University of New Mexico and his M.S. while working at the Lovelace Inhalation Toxicology Research Institute, under Dr. Roger O. McClellan. He then studied inhalation and systemic toxicology at the Institute of Environmental Medicine at New York University, with Drs. Richard B. Schesinger and Dr. Morton Lippmann, receiving his Ph.D. in Environmental Health and Toxicology in 1987. Dr. Gearhart practiced corporate toxicology at The Proctor and Gamble Co after working with Drs. Kenneth Crump at the KS Crump Group and Dr. Harvey Clewell III consulting to a wide range of corporate clients in both the private and government sector.

Dr. Zhoumeng Lin is an Associate Professor in the Department of Environmental and Global Health at College of Public Health and Health Professions at the University of Florida. He is a member of the Center for Environmental and Human Toxicology (CEHT) and the Center for Pharmacometrics and Systems Pharmacology (CPSP). He received a B.Med. in Preventive Medicine from Southern Medical University in China in 2009 and a Ph.D. in Toxicology from the University of Georgia in 2013. He completed his postdoctoral training in Computational Toxicology in the Institute of Computational Comparative Medicine at Kansas State University in 2016. He was an Assistant Professor from 2016 to 2021 and then an Associate Professor from March to May 2021 at Kansas State University, prior to joining the University of Florida as an Associate Professor in May 2021. Dr. Lin’s research is focused on the development and application of computational technologies, especially physiologically based pharmacokinetic (PBPK) modeling, machine learning, and artificial intelligence approaches, to study nanomedicine, food safety, nanoparticle and chemical risk assessment. He is a co-author of more than 100 peer-reviewed manuscripts. He teaches two graduate level courses entitled “Physiologically Based Pharmacokinetic Modeling in Toxicology and Risk Assessment” and “Artificial Intelligence in Toxicology and Environmental Health”.

Details zur Ausgabe

• Verlag: Academic Press
• Erscheinungsdatum: 2020
• Sprache: Englisch
• ISBN 10: 0128185961
• ISBN 13: 9780128185964
• Einband: Taschenbuch
• Anzahl der Seiten: 346
• Herausgeber: Fisher PhD Jeffrey W., Gearhart Jeffery M., Lin PhD Zhoumeng
• Kontakt zum Hersteller: Academic Press; https://shop.elsevier.com/; ; 230 PARK AVENUE, SUITE 800; NY; NY; 10169; USA
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