The aim of this book is provide an accessible introduction to Coalescent Theory with a view towards data analysis.
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Paperback. Zustand: new. Paperback. Coalescent theory is a central concept in the study of genetic sequence variation that probabilistically describes the genealogy relating the sampled sequences. In this text, besides fulfilling the glaring need for such a book, the authors present this theory in a straightforward and elementary manner and describe the statistical and computational methods used in modelling and analyzing genetic sequence variation.Rich in examples andillustrations the book covers basic concepts, complications arising from geographical structure and recombination before considering aspects of statistical inference based on these models. The book ends withchapters on Gene Mapping, which combines sequence variation data with phenotypic data (such as disease) to define areas of the genome where genes are responsible for the trait, and Human Evolution, a research area that is experiencing a renaissance due to the enormous amounts of data produced in molecular studies.Authored by leading experts, this seminal text presents a straightforward and elementary account of coalescent theory, which is a central concept in the study ofgenetic sequence variation observed in a population. It is highly suitable for a graduate course in statistics, population, molecular and medical genetics, bioscience and medicine and studentsstudying the evolution of human population and disease, and will be an invaluable reference for bioscientists and statisticians in the pharmaceutical industry and academia Authored by leading experts, this seminal text presents an account of coalescent theory, which is a central concept in the study of genetic sequence variation observed in a population. It contains many examples and illustrations and is for a graduate course in statistics, population, molecular and medical genetics, bioscience and medicine. This item is printed on demand. Shipping may be from our Sydney, NSW warehouse or from our UK or US warehouse, depending on stock availability. Bestandsnummer des Verkäufers 9780198529965
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Paperback. Zustand: new. Paperback. Coalescent theory is a central concept in the study of genetic sequence variation that probabilistically describes the genealogy relating the sampled sequences. In this text, besides fulfilling the glaring need for such a book, the authors present this theory in a straightforward and elementary manner and describe the statistical and computational methods used in modelling and analyzing genetic sequence variation.Rich in examples andillustrations the book covers basic concepts, complications arising from geographical structure and recombination before considering aspects of statistical inference based on these models. The book ends withchapters on Gene Mapping, which combines sequence variation data with phenotypic data (such as disease) to define areas of the genome where genes are responsible for the trait, and Human Evolution, a research area that is experiencing a renaissance due to the enormous amounts of data produced in molecular studies.Authored by leading experts, this seminal text presents a straightforward and elementary account of coalescent theory, which is a central concept in the study ofgenetic sequence variation observed in a population. It is highly suitable for a graduate course in statistics, population, molecular and medical genetics, bioscience and medicine and studentsstudying the evolution of human population and disease, and will be an invaluable reference for bioscientists and statisticians in the pharmaceutical industry and academia Authored by leading experts, this seminal text presents an account of coalescent theory, which is a central concept in the study of genetic sequence variation observed in a population. It contains many examples and illustrations and is for a graduate course in statistics, population, molecular and medical genetics, bioscience and medicine. This item is printed on demand. Shipping may be from multiple locations in the US or from the UK, depending on stock availability. Bestandsnummer des Verkäufers 9780198529965