Acquired chromosome abnormalities are associated with malignancy, exposure to mutagenic agents, and some chromosome instability syndromes. Their study often entails extensive modification of standard cytogenetic techniques as well as a very different approach to analysis. This is the first comprehensive manual of techniques for the study of acquired chromosome abnormalities, and as such will be an invaluable source of information for cytogeneticists, hematologists, and oncologists. Since the interpretation of chromosome preparations is notoriously difficult in some of these conditions, illustrations, both diagrammatic and photographic, of all chromosome rearrangements discussed are an important feature of this book. In addition to basic techniques, the book takes a futuristic look at new technology which is becoming important in the study of cytogenetics, particularly in the field of cancer research.
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This volume serves as a tool for the cytogeneticist delving for the first time into work with malignant tissue as well as for the more experienced worker hoping to expand his/her range of techniques and seeks to provide some insight into the differing approaches required for the preparation of such material.
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