Excerpt from Notes Upon Cardiac Hypertrophy
In the first place, if we study the causes of hypertrophied heart, whether of hypertrophy of one or both sides, we see this that reading the clinical history of these cases the assigned causes of hypertrophy may be summed up under the heading of increased work. This one heading may be subdivided into three, increased work due to resistance from within, increased work due to resistance from Without, increased work due to nervous stimulation and augmentor action. I shall not discuss this last subdivision, because frankly we are ignorant how far the hypertrophy that occurs in exophthalmic goitre and allied conditions is due to heightened blood pressure, and how far it is secondary to excitation of the accelerators or augmentors.
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