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Cytochromes P-450 and B5- Structure, Function and Interaction- 2nd Philadelphia Conference on Heme Protein P-450- Papers and Discussions - Hardcover

 
9780306390586: Cytochromes P-450 and B5- Structure, Function and Interaction- 2nd Philadelphia Conference on Heme Protein P-450- Papers and Discussions

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P-450 has in common with our nation that it can call Phila- delphia its hometown. Yet there are differences, too. The U. S. A. was born and named in this city. P-450 was first recog- nized here -- an odd CO-combining pigment without family or func- tion. Japanese workers identified it as an unusual member of the cytochrome family. Finally, in Philadelphia, its biological func- tion was established and its growth to a global power initiated. Since discovery of its function as terminal oxidase of the 21-steroid hydroxylase system of adrenocortical microsomes, P-450 has proved to play the same role in a wide variety of other mixed function oxidase systems involved in biosynthesis and catabolism of specific cell or body components as well as in the metabolism of foreign substances entering organisms. P-450-like oxygenating enzymes appear to be fundamental cellular constituents in most forms of aerobic organisms. Activation of molecular oxygen and incorporation of one of its atoms into organic compounds as cata- lyzed by P-450 enzymes are reactions of vital importance not only for biosynthesis and degradation of steroid hormones necessary for sustaining life, but also for metabolic activation or inactivation of foreign agents such as drugs, food preservatives and additives, insecticides and carcinogens. Moreover, P-450 linked enzyme sys- tems can either be induced or suppressed by these agents with significant biological consequences.

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P-450 has in common with our nation that it can call Phila­ delphia its hometown. Yet there are differences, too. The U. S. A. was born and named in this city. P-450 was first recog­ nized here -- an odd CO-combining pigment without family or func­ tion. Japanese workers identified it as an unusual member of the cytochrome family. Finally, in Philadelphia, its biological func­ tion was established and its growth to a global power initiated. Since discovery of its function as terminal oxidase of the 21-steroid hydroxylase system of adrenocortical microsomes, P-450 has proved to play the same role in a wide variety of other mixed function oxidase systems involved in biosynthesis and catabolism of specific cell or body components as well as in the metabolism of foreign substances entering organisms. P-450-like oxygenating enzymes appear to be fundamental cellular constituents in most forms of aerobic organisms. Activation of molecular oxygen and incorporation of one of its atoms into organic compounds as cata­ lyzed by P-450 enzymes are reactions of vital importance not only for biosynthesis and degradation of steroid hormones necessary for sustaining life, but also for metabolic activation or inactivation of foreign agents such as drugs, food preservatives and additives, insecticides and carcinogens. Moreover, P-450 linked enzyme sys­ tems can either be induced or suppressed by these agents with significant biological consequences.

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9781461590286: Cytochromes P-450 and b5: Structure, Function, and Interaction: 58 (Advances in Experimental Medicine and Biology)

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ISBN 10:  1461590280 ISBN 13:  9781461590286
Verlag: Springer, 2012
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Cooper, David [Editor]
Verlag: Springer, 1975
ISBN 10: 0306390582 ISBN 13: 9780306390586
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Hardcover. Zustand: Good. We are unable to ship to Canada at this time.Ex-Library hardcover no dj (blue boards) with all the usual markings, possible attachments, and library wear. Sun bleached spine. Text block clean and unmarked. Tight binding. Bestandsnummer des Verkäufers MDA1629341

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Cooper, David Y., et al, editors
Verlag: Plenum Press, 1974
ISBN 10: 0306390582 ISBN 13: 9780306390586
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Hardcover. Zustand: UsedGood. Hardcover; Advances in Experimental Medicine and Biology, Volume 58; light fading and shelf wear to exterior; bumps to the upper corners and lower spine end; fading to pages; in good condition with clean text and tight binding. Dust jacket shows scuffing, light soiling, and a few small edge tears. Bestandsnummer des Verkäufers 90593

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Cooper, D Y
Verlag: Plenum Press, 1975
ISBN 10: 0306390582 ISBN 13: 9780306390586
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Zustand: Good. Volume 58. This is an ex-library book and may have the usual library/used-book markings inside.This book has hardback covers. In good all round condition. No dust jacket. Please note the Image in this listing is a stock photo and may not match the covers of the actual item,1200grams, ISBN:0306390582. Bestandsnummer des Verkäufers 3961576

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