Progress in Cell Cycle Research: Volume 2 - Hardcover

Meijer, Laurent

 
9780306455070: Progress in Cell Cycle Research: Volume 2
Hardcover
ISBN 10: 0306455072 ISBN 13: 9780306455070
Verlag: Springer, 1996

Inhaltsangabe

Now in its second year, Progress in Cell Cycle Research was conceived to serve as an up to date introduction to various aspects of the cell division cycle. Although an annual review in any field of scientific investigation can never be as current as desired, especially in the cell cycle field, we hope that this volume will be helpful to students, to recent graduates considering a de1liation in subject and to investigators at the fringe of the cell cycle field wishing to bridge frontiers. An instructive approach to many subjects in biology is often to make comparisons between evolutionary distant organisms. If one is willing to accept that yeast represent a model primitive eukaryote, then it is possible to make some interesting comparisons of cell cycle control mechanisms between mammals and our little unicellular cousins. By and large unicellular organisms have no need for intracellular communication. With the exception of the mating phenomenon in S. cerevisiae and perhaps some nutritional sensing mechanisms, cellular division of yeast proceeds with complete disregard for neighbourly communication. Multicellular organisms on the other hand, depend entirely on intracellular communication to maintain structural integrity. Consequently, elaborate networks have evolved to either prevent or promote appropriate cell division in multicellular organisms. Yet, as described in chapter two the rudimentary mechanisms for fine tuning the cell division cycle in higher eukaryotes are already apparent in yeast.

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Reseña del editor

Now in its second year, Progress in Cell Cycle Research was conceived to serve as an up to date introduction to various aspects of the cell division cycle. Although an annual review in any field of scientific investigation can never be as current as desired, especially in the cell cycle field, we hope that this volume will be helpful to students, to recent graduates considering a de1liation in subject and to investigators at the fringe of the cell cycle field wishing to bridge frontiers. An instructive approach to many subjects in biology is often to make comparisons between evolutionary distant organisms. If one is willing to accept that yeast represent a model primitive eukaryote, then it is possible to make some interesting comparisons of cell cycle control mechanisms between mammals and our little unicellular cousins. By and large unicellular organisms have no need for intracellular communication. With the exception of the mating phenomenon in S. cerevisiae and perhaps some nutritional sensing mechanisms, cellular division of yeast proceeds with complete disregard for neighbourly communication. Multicellular organisms on the other hand, depend entirely on intracellular communication to maintain structural integrity. Consequently, elaborate networks have evolved to either prevent or promote appropriate cell division in multicellular organisms. Yet, as described in chapter two the rudimentary mechanisms for fine tuning the cell division cycle in higher eukaryotes are already apparent in yeast.

Reseña del editor

This cutting-edge volume provides the very latest results of basic research in cell replication, often with a view to potential medical applications, especially new anti-proliferative cancer therapies. The book focuses on intracellular communication - the key to cell division, and hence to the inhibition of division of malignant cells - in terms of such highly evolved mechanisms as cyclin dependent kinases (cdk's). Contributors also examine DNA replication by way of so-called licensing factors, as well as the role of genes such as p53, known as the tumor suppressor gene. Other chapters painstakingly sift out "peripheral" agents such as cdk5 and cdk8.

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Verlag
Springer
Erscheinungsdatum
1996
Sprache
Englisch
ISBN 10 
0306455072
ISBN 13 
9780306455070
Einband
Tapa dura
Anzahl der Seiten
300
Herausgeber
Meijer Laurent, Guidet Silvana
Kontakt zum Hersteller
Nicht verfügbar
Verantwortliche Person
CMN Printpool Inh. Mathis Neumann
https://www.also.com/ec/cms5/en_6000/6000/index.jsp

Friedrich-Karl-Str. 9
Hamburg
Deutschland

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