Structural Genomics and High Throughput Structural Biology - Softcover

Softcover

ISBN 10: 0367392232 ISBN 13: 9780367392239

Verlag: Routledge, 2019

Inhaltsangabe

Researchers in structural genomics continue to search for biochemical and cellular functions of proteins as well as the ways in which proteins assemble into functional pathways and networks using either experimental or computational approaches. Based on the experience of leading international experts, Structural Genomics and High Throughput Structural Biology details state-of-the-art analytical and computational methods used to reveal the three-dimensional structure and function of proteins.

A historical perspective and a detailed guide to the production of protein material for structural determination, a key step in the process, lay the necessary foundation for discussing the most effective structure determination technologies, such as X-ray crystallography and NMR spectroscopy. Encouraging the study of genes and proteins of unknown structure in order to discover new information about folding, specific structural features, or function, Structural Genomics and High Throughput Structural Biology presents the methods used to interpret the sequences of proteins in a structural context, giving insight into their function. It also explains how to extract information from public data repositories and how to account for variability and accuracy in the quality of this data.

The book concludes with a discussion of practical applications of therapeutically driven structural genomics, and presents future directions in the field. Structural Genomics and High Throughput Structural Biology offers a comprehensive guide to the theoretical, technological, and experimental methodologies used to derive structural information from encoded proteins by renowned and world leading scientists in the field.

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Michael Sundström, Martin Norin, Aled Edwards

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Assembled by leaders from the Structural Genomics Consortium at Oxford and Toronto Universities, one of the largest research efforts in the world, this book details state-of-the-art analytical and computational methods used to reveal the three-dimensional structure of proteins and explains how to interpret the information to elucidate protein function. From basic discovery through practical applications of therapeutically driven structural genomics, this book presents a comprehensive overview of the field. It features the works and experience of leading international experts and editors who convey extensive practical insight and suggest future directions in the field.

Details zur Ausgabe

• Verlag: Routledge
• Erscheinungsdatum: 2019
• Sprache: Englisch
• ISBN 10: 0367392232
• ISBN 13: 9780367392239
• Einband: Taschenbuch
• Auflage: 1
• Anzahl der Seiten: 285
• Herausgeber: Sundstrom Michael, Norin Martin, Edwards Aled
• Kontakt zum Hersteller: preigu GmbH & Co. KG; mail@preigu.de; ; Lengericher Landstr. 19; Osnabrück; Niedersachsen; 49078; Deutschland