Statistical Methods for Survival Trial Design: With Applications to Cancer Clinical Trials Using R (Chapman & Hall/CRC Biostatistics) - Softcover

Buch 90 von 155: Chapman & Hall/CRC Biostatistics

Wu, Jianrong

 
9780367734329: Statistical Methods for Survival Trial Design: With Applications to Cancer Clinical Trials Using R (Chapman & Hall/CRC Biostatistics)
Softcover
ISBN 10: 036773432X ISBN 13: 9780367734329
Verlag: Routledge, 2020

Inhaltsangabe

Statistical Methods for Survival Trial Design: With Applications to Cancer Clinical Trials Using R provides a thorough presentation of the principles of designing and monitoring cancer clinical trials in which time-to-event is the primary endpoint. Traditional cancer trial designs with time-to-event endpoints are often limited to the exponential model or proportional hazards model. In practice, however, those model assumptions may not be satisfied for long-term survival trials.



This book is the first to cover comprehensively the many newly developed methodologies for survival trial design, including trial design under the Weibull survival models; extensions of the sample size calculations under the proportional hazard models; and trial design under mixture cure models, complex survival models, Cox regression models, and competing-risk models. A general sequential procedure based on the sequential conditional probability ratio test is also implemented for survival trial monitoring. All methodologies are presented with sufficient detail for interested researchers or graduate students.

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Über die Autorin bzw. den Autor

Jianrong (John) Wu is a professor in the Division of Cancer Biostatistics, Department of Biostatistics, Markey Cancer Center, University of Kentucky. He has more than 15 years’ experience of designing and conducting cancer clinical trials at St. Jude Children’s Research Hospital and has developed several novel statistical methods for designing phase II and phase III survival trials.



 



 

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Verlag
Routledge
Erscheinungsdatum
2020
Sprache
Englisch
ISBN 10 
036773432X
ISBN 13 
9780367734329
Einband
Taschenbuch
Anzahl der Seiten
273
Kontakt zum Hersteller
Nicht verfügbar
Verantwortliche Person
Buchbär
info@buchbaer.de

Weberstr. 67
Osnabrück
49084
Deutschland

Weitere beliebte Ausgaben desselben Titels

9781138033221: Statistical Methods for Survival Trial Design: With Applications to Cancer Clinical Trials Using R (Chapman & Hall/CRC Biostatistics)

Vorgestellte Ausgabe

ISBN 10:  1138033227 ISBN 13:  9781138033221
Verlag: Chapman and Hall/CRC, 2018
Hardcover