Statistical Methods in Drug Combination Studies (Chapman & Hall/CRC Biostatistics) - Softcover

Buch 50 von 151: Chapman & Hall/CRC Biostatistics
 
9780367738624: Statistical Methods in Drug Combination Studies (Chapman & Hall/CRC Biostatistics)
Softcover
ISBN 10: 0367738627 ISBN 13: 9780367738624
Verlag: Routledge, 2020

Inhaltsangabe

The growing interest in using combination drugs to treat various complex diseases has spawned the development of many novel statistical methodologies. The theoretical development, coupled with advances in statistical computing, makes it possible to apply these emerging statistical methods in in vitro and in vivo drug combination assessments. However, despite these advances, no book has served as a single source of information for statistical methods in drug combination research, nor has there been any guidance for experimental strategies.



Statistical Methods in Drug Combination Studies fills that gap, covering all aspects of drug combination research, from designing in vitro drug combination studies to analyzing clinical trial data. Featuring contributions from researchers in industry, academia, and regulatory agencies, this comprehensive reference:





  • Describes statistical models used to characterize dose-response patterns of monotherapies and evaluate the combination drug synergy


  • Offers guidance for estimating interaction indices and constructing their associated confidence intervals to assess drug interaction


  • Introduces a practical and innovative Bayesian approach to Phase I cancer trials, including actual trial examples to illustrate use


  • Examines strategies in the fixed-dose combination therapy clinical development via case studies stemming from regulatory reviews


  • Evaluates computational tools and software packages used to apply novel statistical methods in combination drug development


Statistical Methods in Drug Combination Studies provides researchers with a solid understanding of the available statistical methods and computational tools and how to apply them in drug combination studies. The book is equally useful for statisticians to become better equipped to deal with drug combination study design and analysis in their practice.

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Über die Autorin bzw. den Autor

Wei Zhao, Harry Yang

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Verlag
Routledge
Erscheinungsdatum
2020
Sprache
Englisch
ISBN 10 
0367738627
ISBN 13 
9780367738624
Einband
Taschenbuch
Anzahl der Seiten
240
Herausgeber
Zhao Wei, Yang Harry
Kontakt zum Hersteller
preigu GmbH & Co. KG
mail@preigu.de

Lengericher Landstr. 19
Osnabrück
Niedersachsen
49078
Deutschland

Weitere beliebte Ausgaben desselben Titels

9781482216745: Statistical Methods in Drug Combination Studies (Chapman & Hall/CRC Biostatistics Series, Band 69)

Vorgestellte Ausgabe

ISBN 10:  1482216744 ISBN 13:  9781482216745
Verlag: Chapman and Hall/CRC, 2014
Hardcover