Studies of Narcosis: Charles Ernest Overton - Hardcover

Hardcover

ISBN 10: 0412352400 ISBN 13: 9780412352409

Verlag: Springer, 1990

Inhaltsangabe

1 Introduction.- 2 Introduction.- 3 Charles Ernest Overton: narcosis studies and a contribution to general pharmacology.- Studies of Narcosis and a Contribution to General Pharmacology.- Preface.- One General Section.- 1 Background.- 1.1 Introduction.- 1.2 Attempts to distinguish between anaesthetics and narcotics.- 1.3 Inhalation anaesthetics and other non-specific narcotics.- 1.4 Non-specific and basic narcotics.- 1.5 Factors to be considered in developing a theory of narcosis.- 1.6 Relationship between dose and means of administration.- 1.7 Calculation of the concentration of a toxicant in the blood plasma.- 1.8 Conditions affecting blood plasma toxicant concentration.- 1.9 Bert’s method for maintaining a constant concentration of an anaesthetic in the blood.- 1.10 Bert’s experiments with chloroform and ethyl ether.- 1.11 Concentration of an anaesthetic in the blood plasma.- 1.12 The intercellular lymph as a pathway between the blood and the tissue cells.- 1.13 Three groups of compounds differing with respect to their permeability to tissue cells.- 1.13.1 Compounds unable to penetrate living cells.- 1.13.2 Compounds that readily penetrate living cells.- 1.13.3 Compounds that slowly penetrate living cells.- 1.14 Method of producing known and constant concentrations of non-volatile compounds in the blood: limits of applicability.- 2 Critical review of the major hypotheses on the mechanism of narcosis.- 2.1 Hypotheses based upon the circulation in the brain.- 2.2 Hypothesis of Claude Bernard.- 2.3 Hypothesis of Binz.- 2.4 Hypothesis of Dubois.- 2.5 Richet’s principle.- 2.6 Hypotheses based upon the chemical composition of the brain.- 2.6.1 Chemistry of the nervous system.- 2.6.2 Hypothesis of Bibra and Harless.- 2.6.3 Contribution of Hermann.- 2.7 Theory of H. Meyer and the author on narcosis induced by non-specific narcotics.- 3 Lipoid theory of narcosis and partition coefficients.- 3.1 Theory of partition coefficients.- 3.2 Methods for measuring partition coefficients.- 3.2.1 Physical methods.- 3.2.2 Physiological methods.- 3.3 Measurement of partition coefficients between water and cerebral lipoids.- 3.4 General foundation of the lipoid theory of narcosis.- Two Experimental Results.- 4 Narcosis induced by ether and chloroform.- 4.1 Ether narcosis.- 4.1.1 Experiments with ethyl ether.- 4.1.2 Calculation of the ether concentration in the blood plasma of narcotized mammals and man from the data of Bert.- 4.1.3 Concentration of ether in the blood plasma of narcotized tadpoles.- 4.1.4 Concentration of ether in the blood plasma of other narcotized organisms and in narcotized plants.- 4.1.5 Biological transport of ether and other non-specific narcotics into the blood and cerebral lipoids of aquatic organisms.- 4.1.6 Partition coefficient of ether between water and olive oil.- 4.2 Chloroform narcosis.- 4.2.1 Experiments with chloroform.- 4.2.2 Calculations of the chloroform concentration in the blood plasma of mammals from the data of Bert.- 4.2.3 Chloroform concentration in the blood plasma of narcotized tadpoles.- 5 Aliphatic non-electrolyte organic compounds and narcosis.- 5.1 Monohydric alcohols.- 5.2 Aliphatic hydrocarbons and their halogen derivatives.- 5.3 Nitriles and nitroparaffins.- 5.4 Monovalent aldehydes, paraldehyde, chloral hydrate and chloralformamide.- 5.5 Ketones, sulfonals, aldoximes and ketoximes.- 5.6 Esters of mineral acids.- 5.7 Esters of organic acids: significance of the rate of saponification, and effect of the presence of hydroxyl groups.- 5.8 Dihydric and polyhydric alcohols and some of their derivatives.- 5.9 Acid amides: urea and its derivatives.- 5.10 Chloralose.- 6 Aromatic compounds.- 6.1 Aromatic hydrocarbons and azobenzene.- 6.1.1 Potent narcotic action of phenanthrene.- 6.2 Phenols and their ethers, vanillin and piperonal.- 6.2.1 Monovalent phenols and their ethers.- 6.2.2 Divalent phenols and their ethers.- 6.2.3 Vanillin and piperonal.- 6.3 Oil of turpentine, camphor and volatile oils.- 6.4 ...

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Críticas

I would urge other anaesthetists...to read it. They will be pleasantly suprised.' British Journal of Anaesthesia Studies of Narcosis is a valuable and fascinating book, and should be in the library of anyone concerned with the actions of xenobiotics of living organisms.' Xenobiotica

Reseña del editor

This volume is an English translation of Overton's monograph on structure-activity relationships regarding anaesthetic action and toxicity. This book has been cited widely by scientists studying the correlation of biological activity with partition coefficients and the mechanism of anaesthesia. Although the original monograph was published in 1901, it should still be of value to modern toxicologists, particularly those involved in the development of quantitative structure-toxicity relationships and the predictive limitations of such models. Introductory chapters by Lipnick, Miller and Winter emphasize the importance of this text. This book should be of interest to anaesthetists, pharmacologists, toxicologists, medical and organic chemists and pharmaceutical historians.

Details zur Ausgabe

• Verlag: Springer
• Erscheinungsdatum: 1990
• Sprache: Englisch
• ISBN 10: 0412352400
• ISBN 13: 9780412352409
• Einband: Tapa dura
• Anzahl der Seiten: 220
• Herausgeber: Lipnick R.L.
• Kontakt zum Hersteller: Springer Nature Customer Service Center GmbH; ProductSafety@springernature.com; ; Europaplatz 3,69115 Heidelberg, Germany; Heidelberg; 69115; Deutschland