mRNA Therapeutics: Foundations, Innovations, and Clinical Applications - Softcover

Hillery PhD, Anya

Softcover

ISBN 10: 0443289344 ISBN 13: 9780443289347

Verlag: Academic Press, 2024

Inhaltsangabe

mRNA Therapeutics: Foundations, Innovations and Clinical Applications aims to provide a comprehensive text that covers all aspects of mRNA therapeutics, from the foundational science that underpins this disruptive new drug class, through the scientific and technological breakthroughs crucial for therapeutic success, to the current clinical applications and the innovative advances driving future directions.

The book begins with foundational knowledge covering mRNA biology, the immune system, and vaccines. The second section addresses the major challenges associated with mRNA as a therapeutic modality, and the molecular engineering innovations and delivery technologies that have allowed these hurdles to be largely overcome.

The third section describes the current and future clinical applications of mRNA therapeutics that are transforming, or are poised to transform, medicine and health. This includes the use of mRNA vaccines for COVID-19 and other infectious diseases, as well as mRNA's role in revolutionizing cancer immunotherapy, covering immunostimulants, cancer vaccines including personalized neoantigen vaccines, and CAR T cell technologies. Additional chapters describe the use of mRNA therapeutics for protein replacement therapy and gene-editing, as well as newer mRNA constructs, including self-amplifying mRNA. The final section addresses the safety and regulatory considerations of mRNA therapeutics, along with broader cultural issues including vaccine hesitancy, global vaccine inequality, and pandemic preparedness.

Currently, mRNA texts either provide personal accounts from key players involved in COVID-19 vaccine development, with limited scientific depth, or focus on highly specialized, more esoteric applications of mRNA in advanced molecular biology. This book aims to bridge this gap by providing a scientifically rigorous and wide-ranging exploration of mRNA's role in therapeutics.

This pioneering textbook serves as a vital addition to the academic canon, providing an essential tool for the current and next generation of students, scientists, researchers and professionals in a wide variety of related disciplines including molecular biology, biomedical engineering, pharmaceutical science, oncology, and the health sciences.

Über diesen Titel

Über die Autorin bzw. den Autor

Dr. Anya M. Hillery received her BSc in pharmacy from Trinity College Dublin, Ireland, followed by a Ph.D. and post-doctoral research work in the field of vaccines/nanoparticle delivery systems at the School of Pharmacy, University College London, UK. As a Senior Lecturer in the University of Brighton, UK, she led her own research laboratory working on novel delivery systems and oral vaccines. Dr Hillery is currently a Professor of Health Sciences at Saint Louis University, Madrid Campus, Spain and is also a Senior Editor for the journal International Pharmaceutical Quality. She has published widely in peer-reviewed scientific journals, edited two acclaimed books on Drug Delivery & Targeting, and is the recipient of numerous national and international awards for research and scholarship.

Von der hinteren Coverseite

mRNA Therapeutics: Fundamentals and Applications summarizes the scientific development of mRNA vaccines that have revolutionized the way we treat disease. These vaccines work by delivering instructions to our cells to produce proteins, which then trigger an immune response. This approach has the potential to treat a wide range of diseases, including COVID-19, cancer, and infectious diseases. The first section of the book introduces mRNA vaccines, including their history, mechanism of action, and potential applications. The second section delves into the science of mRNA vaccines, covering topics such as the structure of mRNA, the delivery of mRNA to cells, and the immune response to mRNA vaccines. The third section discusses the future of mRNA technology, exploring potential applications such as cancer therapy, prevention of infectious diseases, and replacement of missing or damaged proteins. mRNA Therapeutics: Fundamentals and Applications is a valuable resource for scientists, researchers, and clinicians who are interested in the latest developments in mRNA technology. It is also a useful reference for students and professionals who are working in the fields of biotechnology, pharmaceutical science, and vaccine development.

Details zur Ausgabe

• Verlag: Academic Press
• Erscheinungsdatum: 2024
• Sprache: Englisch
• ISBN 10: 0443289344
• ISBN 13: 9780443289347
• Einband: Taschenbuch
• Auflage: 1
• Anzahl der Seiten: 210
• Kontakt zum Hersteller: Elsevier Science & Technology; tradeorders@elsevier.com; ; London Wall 125; London; EC2Y 5AS; Vereinigtes Königreich
• Verantwortliche Person: Nicht verfügbar