Metal-based Neurodegeneration: From Molecular Mechanisms to Therapeutic Strategies - Hardcover

Crichton, Robert; Ward, Roberta

Hardcover

ISBN 10: 0470022558 ISBN 13: 9780470022559

Verlag: Wiley, 2005

Inhaltsangabe

This exciting new book opens a window into the causes of debilitating neurological disorders such as Parkinson’s disease, CJD and Huntington’s disease, and gives indications of the prospects for therapy, based on the understanding of molecular defects involved in these diseases.

Looking at each specific neurological disorder in turn, the book outlines the role of metals in human biology, in particular in the brain and explores tools for testing potential therapeutic strategies. It concludes with an overview of the potential of both chelation and antioxidant therapy and outlines some perspectives for the future.

Über diesen Titel

Über die Autorin bzw. den Autor

Professor Robert R. Crichton, Unité de Biochimie, Belgium.

Professor Roberta J. Ward, Unité de Biochimie, Belgium.

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As life expectancy increases in the developed world, so does the incidence of neurodegenerative diseases of the human brain. Metal-Based Neurodegeneration provides a molecular biology perspective of many of the neurodegenerative diseases which currently plague humankind, including:

• Alzheimer’s Disease
• Parkinson’s Disease
• Creutzfeldt-Jakob disease
• Familial amyotrophic lateral sclerosis
• Friedreich’s ataxia
• Multiple sclerosis
• Wilson’s disease
• Hallervorden-Spatz syndrome
• Huntington’s disease

In a dedicated chapter for each disease the characteristics of the disease are described along with the biochemical actors, including their normal, and pathological conformations. Emphasis is given on the role of metal-induced oxidative stress in the disease process, often resulting in the production of intracellular aggregates of the target proteins or peptides, including b-amyloid plaques and neurofibrillary tangles in Alzheimer’s disease, Lewy bodies in Parkinson’s disease, prion protein (PrP) plaques in prion diseases and nuclear inclusions in Huntington’s. Finally the authors discuss the progress that is being made in understanding the pathogenesis of the diseases and the identification of targets for their treatment.

Metal-Based Neurodegeneration is an essential survey of the molecular origin of neurodegenerative diseases for clinical and research scientists working in gerontology, neuropathology, metalloprotein mechanisms, and anyone with an interest in the diseases of ageing.

• Alzheimer’s Disease
• Parkinson’s Disease
• Creutzfeldt-Jakob disease
• Familial amyotrophic lateral sclerosis
• Friedreich’s ataxia
• Multiple sclerosis
• Wilson’s disease
• Hallervorden-Spatz syndrome
• Huntington’s disease

In a dedicated chapter for each disease the characteristics of the disease are described along with the biochemical actors, including their normal, and pathological conformations. Emphasis is given on the role of metal-induced oxidative stress in the disease process, often resulting in the production of intracellular aggregates of the target proteins or peptides, including b-amyloid plaques and neurofibrillary tangles in Alzheimer’s disease, Lewy bodies in Parkinson’s disease, prion protein (PrP) plaques in prion diseases and nuclear inclusions in Huntington’s. Finally the authors discuss the progress that is being made in understanding the pathogenesis of the diseases and the identification of targets for their treatment.

Metal-Based Neurodegeneration is an essential survey of the molecular origin of neurodegenerative diseases for clinical and research scientists working in gerontology, neuropathology, metalloprotein mechanisms, and anyone with an interest in the diseases of ageing.

Details zur Ausgabe

• Verlag: Wiley
• Erscheinungsdatum: 2005
• Sprache: Englisch
• ISBN 10: 0470022558
• ISBN 13: 9780470022559
• Einband: Gebundene Ausgabe
• Auflage: 1
• Anzahl der Seiten: 240
• Kontakt zum Hersteller: Wiley-VCH GmbH; product_safety@wiley.com; ; Boschstrasse 12; Weinheim; 69469; Deutschland