Structure-Function Analysis of G Protein-Coupled Receptors: 3 (Receptor Biochemistry and Methodology) - Hardcover

Hardcover

ISBN 10: 047125228X ISBN 13: 9780471252283

Verlag: Wiley-Liss Inc.,U.S., 1999

Inhaltsangabe

G protein-coupled receptors (GPCRs) are the largest single class of receptors in biology, often playing key roles in a remarkably large number of physiological and pathophysiological conditions. GPCRs or GPCR-dependent signalling pathways are the targets of a very large number of therapeutically useful drugs. Detailed knowledge about the molecular structure of GPCRs should therefore pave the way for the design of novel drugs with increased efficacy and specificity.

This volume provides a concise, up-to-date presentation of methods (including molecular genetic, biochemical, and biophysical) which have been used successfully in studying the structure and function of GPCRs. With contributions from international leaders in the field, the editor provides overviews of various techniques, followed by in-depth descriptions of basic procedures and discussions of critical experimental parameters.

Divided into specific, accessible sections, Structure-Function Analysis of G Protein-Coupled Receptors includes:
* An overview of mutagenesis techniques
* Examples of molecular modeling techniques
* Using peptides as tools for the study of GPCR interactions
* Site-Directed Spin Labeling (SDSL) studies of the GPCR rhodopsin
* A complete description of the electron-crystalographic analysis of two-dimensional rhodopsin crystals
* The use of nuclear magnetic resonance techniques to study GPCR structure

Über diesen Titel

Über die Autorin bzw. den Autor

Jürgen Wess is the author of Structure-Function Analysis of G Protein-Coupled Receptors, published by Wiley.

Von der hinteren Coverseite

Structure-Function Analysis of G Protein-Coupled Receptors edited by Jürgen Wess.

G protein-coupled receptors (GPCRs) are the largest single class of receptors in biology, playing key roles in a remarkably large number of physiological and pathophysiological conditions. GPCRs or GPCR-dependent signalling pathways are the targets of a very large number of therapeutically useful drugs. Detailed knowledge about the molecular structure of GPCRs should therefore pave the way for the design of novel drugs with increased efficacy and specificity.

This volume provides a concise, up-to-date presentation of methods (including molecular genetic, biochemical, and biophysical) which have been used successfully in studying the structure and function of GPCRs. With contributions from international leaders in the field, the editor provides overviews of various techniques, followed by in-depth descriptions of basic procedures and discussions of critical experimental parameters.

Divided into specific, accessible sections, Structure-Function Analysis of G Protein-Coupled Receptors includes:
* An overview of mutagenesis techniques.
* Examples of molecular modeling techniques.
* Using peptides as tools for the study of GPCR interactions.
* Site-Directed Spin Labeling (SDSL) studies of the GPCR rhodopsin.
* A complete description of the electron-crystallographic analysis of two-dimensional rhodopsin crystals.
* The use of nuclear magnetic resonance techniques to study GPCR structure.

Structure-Function Analysis of G Protein-Coupled Receptors is an invaluable reference for receptor biochemists and biological chemists, pharmacologists, and neuroscientists as well as molecular biologists, cell biologists, and structural biologists worldwide.

Also in this series: Receptor Localization:
* Laboratory Methods and Procedures edited by Marjorie A. Ariano.
* Identification and Expression of G Protein-Coupled Receptors edited by Kevin R. Lynch.

Aus dem Klappentext

Structure-Function Analysis of G Protein-Coupled Receptors edited by JÃ1/4rgen Wess.

G protein-coupled receptors (GPCRs) are the largest single class of receptors in biology, playing key roles in a remarkably large number of physiological and pathophysiological conditions. GPCRs or GPCR-dependent signalling pathways are the targets of a very large number of therapeutically useful drugs. Detailed knowledge about the molecular structure of GPCRs should therefore pave the way for the design of novel drugs with increased efficacy and specificity.

This volume provides a concise, up-to-date presentation of methods (including molecular genetic, biochemical, and biophysical) which have been used successfully in studying the structure and function of GPCRs. With contributions from international leaders in the field, the editor provides overviews of various techniques, followed by in-depth descriptions of basic procedures and discussions of critical experimental parameters.

Divided into specific, accessible sections, Structure-Function Analysis of G Protein-Coupled Receptors includes:
* An overview of mutagenesis techniques.
* Examples of molecular modeling techniques.
* Using peptides as tools for the study of GPCR interactions.
* Site-Directed Spin Labeling (SDSL) studies of the GPCR rhodopsin.
* A complete description of the electron-crystallographic analysis of two-dimensional rhodopsin crystals.
* The use of nuclear magnetic resonance techniques to study GPCR structure.

Structure-Function Analysis of G Protein-Coupled Receptors is an invaluable reference for receptor biochemists and biological chemists, pharmacologists, and neuroscientists as well as molecular biologists, cell biologists, and structural biologists worldwide.

Also in this series: Receptor Localization:
* Laboratory Methods and Procedures edited by Marjorie A. Ariano.
* Identification and Expression of G Protein-Coupled Receptors edited by Kevin R. Lynch.

Details zur Ausgabe

• Verlag: Wiley-Liss Inc.,U.S.
• Erscheinungsdatum: 1999
• Sprache: Englisch
• ISBN 10: 047125228X
• ISBN 13: 9780471252283
• Einband: Tapa dura
• Anzahl der Seiten: 432
• Herausgeber: Wess Jürgen
• Kontakt zum Hersteller: Nicht verfügbar
• Verantwortliche Person: Nicht verfügbar