Exploration and Analysis of DNA Microarray and Protein Array Data (Wiley Series in Probability and Statistics) - Hardcover

Amaratunga, Dhammika; Cabrera, Javier

Hardcover

ISBN 10: 0471273988 ISBN 13: 9780471273981

Verlag: John Wiley & Sons, 2003

Inhaltsangabe

The emergence of genomics, the study of genes, is one of the major scientific revolutions of this century. Microarrays, a method used to analyze numerous DNA samples rapidly, enables scientists to make sense of this mountain of data using statistical analysis. They are being used in such areas of biomedical research as studying patterns for gene activity that cause cancers to spread. This book presents a comprehensive methodology for analyzing DNA microarray and protein array data.
The most comprehensive treatment of this important emerging field, Exploration and Analysis of DNA Microarray and Protein Array Data includes:
A review of basic molecular biology and a chapter introducing microarrays and their preparation
Chapters on processing scanned images, preprocessing microarray data, group comparative experiments, and other designs
Discussions of clustering, protein arrays, and applications for diagnostic tools
Ample exercises assist absorbtion

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Über die Autorin bzw. den Autor

DHAMMIKA AMARATUNGA, PhD, is a Senior Research Fellow in the Nonclinical Biostatistics Department at Johnson & Johnson Pharmaceutical Research & Development, LLC. He has a doctorate in statistics from Princeton University and has been working in the pharmaceutical industry for over fifteen years. His research interests include analysis of large multivariate data sets, particularly those generated by functional genomics research, robust and resistant statistical methods, linear and nonlinear modeling, and biostatistics.
 
JAVIER CABRERA, PhD, is an Associate Professor in the Department of Statistics at Rutgers University. He has a doctorate in statistics from Princeton University and has over fifty publications in applied statistics. His research interests include DNA microarray, data mining of biopharmaceutical databases, computer vision, statistical computing and graphics, robustness, and biostatistics.

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A cutting-edge guide to the analysis of DNA microarray data
 
Genomics is one of the major scientific revolutions of this century, and the use of microarrays to rapidly analyze numerous DNA samples has enabled scientists to make sense of mountains of genomic data through statistical analysis. Today, microarrays are being used in biomedical research to study such vital areas as a drug's therapeutic value-or toxicity-and cancer-spreading patterns of gene activity.
 
Exploration and Analysis of DNA Microarray and Protein Array Data answers the need for a comprehensive, cutting-edge overview of this important and emerging field. The authors, seasoned researchers with extensive experience in both industry and academia, effectively outline all phases of this revolutionary analytical technique, from the preprocessing to the analysis stage.
 
Highlights of the text include:
* A review of basic molecular biology, followed by an introduction to microarrays and their preparation
* Chapters on processing scanned images and preprocessing microarray data
* Methods for identifying differentially expressed genes in comparative microarray experiments
* Discussions of gene and sample clustering and class prediction
* Extension of analysis methods to protein array data
 
Numerous exercises for self-study as well as data sets and a useful collection of computational tools on the authors' Web site make this important text a valuable resource for both students and professionals in the field.

Details zur Ausgabe

• Verlag: John Wiley & Sons
• Erscheinungsdatum: 2003
• Sprache: Englisch
• ISBN 10: 0471273988
• ISBN 13: 9780471273981
• Einband: Gebundene Ausgabe
• Auflage: 1
• Anzahl der Seiten: 272
• Kontakt zum Hersteller: Nicht verfügbar
• Verantwortliche Person: Nicht verfügbar