Perspectives in Molecular Toxinology - Hardcover

Hardcover

ISBN 10: 0471495034 ISBN 13: 9780471495031

Verlag: Wiley, 2002

Inhaltsangabe

Covering the most recent advances in our understanding of toxins from venomous animals and microbes as well as that of their targets, this book expertly addresses the many intriguing and unsolved questions concerning; proteomics studies of the "toxinome", intimate modes of toxin actions, molecular basis of specificity, pleiotropic properties of toxins and structural biology of toxins.

Through twenty-seven chapters the authors discuss the role of structural genomics in toxinology, how toxins are subject to accelerated evolution, how toxins can be exploited as models for the design of new drugs, and what the future holds for the treatment of snake bites.

In order to address these challenging aspects, the authors have posed crystal-clear questions. Based on the most precise knowledge the attendant reasoning shows how toxinology has become an important area of biochemistry and is directly associated with advances in cellular microbiology, molecular pharmacology, molecular physiology, cell biology, protein engineering and many other disciplines.

Über diesen Titel

Über die Autorin bzw. den Autor

Andre Menez is the Director of the Department of Protein Engineering at the Commissariat a l'Energie Atomique (CEA) in France. He heads the Laboratory of Protein Chemistry and is Professor at the National Institute of Sciences and Nuclear Techniques.

Von der hinteren Coverseite

In this volume the editors have reviewed the most recent major advances in our understanding of toxins from venomous animals and microbes and their targets in mammals, insects and other animals. To approach these challenging aspects, the authors have posed crystal-clear questions based on the most precise acquired knowledge.
* What can be learnt from genomics and proteomics?

* What are the intimate modes of action of toxins on ion channels, receptors, enzymes, cell membranes?

* What is the molecular basis of specificity and more generally of pleiotropism of toxins?

* What else can be learnt about toxin tertiary structures and dynamics?

* How can we enhance our understanding of target architecture and complex toxin-target structures?

* Are toxins subject to accelerated evolution?

* Can they be exploited as models for the design of new drugs?

* What does the future hold for the treatment of snake bites?
These are just some of the many questions that have been addressed in this book. Complete answers may not always be readily apparent, but the attendant reasoning shows how toxinology has become an important area of biochemistry, directly associated with advances in cellular microbiology, molecular pharmacology, molecular physiology, cell biology, protein engineering, and other disciplines.

Aus dem Klappentext

In this volume the editors have reviewed the most recent major advances in our understanding of toxins from venomous animals and microbes and their targets in mammals, insects and other animals. To approach these challenging aspects, the authors have posed crystal-clear questions based on the most precise acquired knowledge. * What can be learnt from genomics and proteomics?

* What are the intimate modes of action of toxins on ion channels, receptors, enzymes, cell membranes?

* What is the molecular basis of specificity and more generally of pleiotropism of toxins?

* What else can be learnt about toxin tertiary structures and dynamics?

* How can we enhance our understanding of target architecture and complex toxin-target structures?

* Are toxins subject to accelerated evolution?

* Can they be exploited as models for the design of new drugs?

* What does the future hold for the treatment of snake bites? These are just some of the many questions that have been addressed in this book. Complete answers may not always be readily apparent, but the attendant reasoning shows how toxinology has become an important area of biochemistry, directly associated with advances in cellular microbiology, molecular pharmacology, molecular physiology, cell biology, protein engineering, and other disciplines.

Details zur Ausgabe

• Verlag: Wiley
• Erscheinungsdatum: 2002
• Sprache: Englisch
• ISBN 10: 0471495034
• ISBN 13: 9780471495031
• Einband: Gebundene Ausgabe
• Auflage: 1
• Anzahl der Seiten: 528
• Herausgeber: Ménez A.
• Kontakt zum Hersteller: Wiley-VCH GmbH; product_safety@wiley.com; ; Boschstrasse 12; Weinheim; 69469; Deutschland