RNA Interference: Application to Drug Discovery and Challenges to Pharmaceutical Development - Hardcover

Hardcover

ISBN 10: 0471771511 ISBN 13: 9780471771517

Verlag: Wiley, 2011

Inhaltsangabe

RNA Interference: Application to Drug Discovery and Challenges to Pharmaceutical Development provides a general overview of this rapidly emerging field, with a strong emphasis on issues and aspects that are important to a drug development team. The first part covers more general background of RNA interference and its application in drug discovery. In the second part, the book addresses siRNA (small interfering RNA), a pharmaceutically potent form, and its use and delivery in therapeutics along with manufacturing and delivery aspects.

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Über die Autorin bzw. den Autor

PAUL H. JOHNSON, PhD, is a cofounder and Chief Scientific Officer at PhaseRx, Inc. He is the author of numerous scientific papers and patents, and was the recipient of the 2007 Jeffrey Wenig Memorial Award for Outstanding Achievement in Drug Delivery.

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A general overview of RNA interference for the novice reader

Today, RNA molecules are used extensively in academic labs and the pharmaceutical industry to probe gene function and validate gene and protein targets for drug discovery. This book provides an overview of RNA interference for those unfamiliar with this rapidly emerging field. It covers mechanisms of action, its applications as a target validation and identification tool, toxicity concerns, and development of siRNA molecules as novel therapeutics.

Written by experts in the field, each chapter focuses on an important aspect of RNAi biology or therapeutic discovery and application. While various aspects of current research, important discoveries, technology description, and methodology are covered, the book focuses on identifying issues that must be overcome for the successful development of RNAi technology. With a strong emphasis on issues and aspects that are important to a drug development team, the book:

• Presents a general overview of RNA interference biology, along with a strong emphasis on therapeutic applications issues important for drug development

• Addresses siRNA (small interfering RNA), a pharmaceutically-potent form, and how it is used in therapeutics, along with toxicity and delivery aspects

• Emphasizes industrial applications such as chemical modifications and delivery

• Focuses on gene function validation and siRNA as a new class of therapeutics

• Includes pharmaceutical topics of discovery and development of delivery agents, toxicity, and viral disease applications

Clear, easy to understand, and focused on key issues for future research and development, RNA Interference is intended for non-specialist scientists, working in both academia and the pharmaceutical industry, who need to know and work within the dynamic area of RNA interference.

Aus dem Klappentext

A general overview of RNA interference for the novice reader

Today, RNA molecules are used extensively in academic labs and the pharmaceutical industry to probe gene function and validate gene and protein targets for drug discovery. This book provides an overview of RNA interference for those unfamiliar with this rapidly emerging field. It covers mechanisms of action, its applications as a target validation and identification tool, toxicity concerns, and development of siRNA molecules as novel therapeutics.

Written by experts in the field, each chapter focuses on an important aspect of RNAi biology or therapeutic discovery and application. While various aspects of current research, important discoveries, technology description, and methodology are covered, the book focuses on identifying issues that must be overcome for the successful development of RNAi technology. With a strong emphasis on issues and aspects that are important to a drug development team, the book:

• Presents a general overview of RNA interference biology, along with a strong emphasis on therapeutic applications issues important for drug development

• Addresses siRNA (small interfering RNA), a pharmaceutically-potent form, and how it is used in therapeutics, along with toxicity and delivery aspects

• Emphasizes industrial applications such as chemical modifications and delivery

• Focuses on gene function validation and siRNA as a new class of therapeutics

• Includes pharmaceutical topics of discovery and development of delivery agents, toxicity, and viral disease applications

Clear, easy to understand, and focused on key issues for future research and development, RNA Interference is intended for non-specialist scientists, working in both academia and the pharmaceutical industry, who need to know and work within the dynamic area of RNA interference.

Details zur Ausgabe

• Verlag: Wiley
• Erscheinungsdatum: 2011
• Sprache: Englisch
• ISBN 10: 0471771511
• ISBN 13: 9780471771517
• Einband: Gebundene Ausgabe
• Auflage: 1
• Anzahl der Seiten: 336
• Herausgeber: Johnson Paul H.
• Kontakt zum Hersteller: Wiley-VCH GmbH; product_safety@wiley.com; ; Boschstrasse 12; Weinheim; 69469; Deutschland