The concept of membrane receptors as components that recognize extracellular ligands and translate their binding into appropriate intracellular responses has been central to pharmacology for more than a century. However, the last few years have seen developments at the molecular level, transforming the discipline of pharmacology. This study examines the latest developments in receptor structure, transmembrane signalling, second messenger generation and second messenger action. It provides access to each of these areas and gives an overview for the future drug manipulation of transmembrane signalling.
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