Modeling Infectious Diseases in Humans and Animals - Hardcover

Keeling, Matt J.; Rohani, Pejman

Hardcover

ISBN 10: 0691116172 ISBN 13: 9780691116174

Verlag: PRINCETON UNIV PR, 2007

Inhaltsangabe

For epidemiologists, evolutionary biologists, and health-care professionals, real-time and predictive modeling of infectious disease is of growing importance. This book provides a timely and comprehensive introduction to the modeling of infectious diseases in humans and animals, focusing on recent developments as well as more traditional approaches.

Matt Keeling and Pejman Rohani move from modeling with simple differential equations to more recent, complex models, where spatial structure, seasonal "forcing," or stochasticity influence the dynamics, and where computer simulation needs to be used to generate theory. In each of the eight chapters, they deal with a specific modeling approach or set of techniques designed to capture a particular biological factor. They illustrate the methodology used with examples from recent research literature on human and infectious disease modeling, showing how such techniques can be used in practice. Diseases considered include BSE, foot-and-mouth, HIV, measles, rubella, smallpox, and West Nile virus, among others. Particular attention is given throughout the book to the development of practical models, useful both as predictive tools and as a means to understand fundamental epidemiological processes. To emphasize this approach, the last chapter is dedicated to modeling and understanding the control of diseases through vaccination, quarantine, or culling.

• Comprehensive, practical introduction to infectious disease modeling
• Builds from simple to complex predictive models
• Models and methodology fully supported by examples drawn from research literature
• Practical models aid students' understanding of fundamental epidemiological processes
• For many of the models presented, the authors provide accompanying programs written in Java, C, Fortran, and MATLAB
• In-depth treatment of role of modeling in understanding disease control

Über diesen Titel

Über die Autorin bzw. den Autor

Matt J. Keeling is professor in the Department of Biological Sciences and the Mathematics Institute at the University of Warwick. Pejman Rohani is associate professor in the Institute of Ecology and the Center for Tropical and Emerging Global Diseases at the University of Georgia.

Von der hinteren Coverseite

"Mathematical models of infectious disease have proven to be a valuable component of public health planning and response, as well as an important application of population biology. Keeling and Rohani have written an accessible and much-needed introduction to this field that will be suitable for graduate students and advanced undergraduates alike."--Carl T. Bergstrom, University of Washington

"Mathematical models are now as crucial in the study of infectious diseases as are microscopes, stethoscopes, and the tools of molecular diagnosis. These models have contributed to epidemiological understanding at all levels, from projections of the magnitude of the AIDS epidemic to an understanding of the within-host interactions between pathogens and the host's immune system. This book outlines all the major developments in mathematical epidemiology that have occurred since the publication of Anderson and May's classic synthesis in Infectious Diseases of Humans. It is highly recommended to all students of infectious disease biology who require a detailed and well-organized introduction to the mathematical models needed to understand the dynamics of infectious diseases."--Andrew Dobson, Princeton University

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Modeling Infectious Diseases in Humans and Animals

By Matt J. Keeling Pejman Rohani

Princeton University Press

Copyright © 2007 Princeton University Press
All right reserved.
ISBN: 978-0-691-11617-4

Chapter One

Introduction

This book is designed as an introduction to the modeling of infectious diseases. Westart with the simplest of mathematical models and show how the inclusion of appropriate elements of biological complexity leads to improved understanding of disease dynamics and control. Throughout, our emphasis is on the development of models, and their use either as predictive tools or as a means of understanding fundamental epidemiological processes. Although many theoretical results can be proved analytically for very simple models, we have generally focused on results obtained by computer simulation, providing analytical results only where they lead to a more generic interpretation of model behavior. Where practical, we have illustrated the general modeling Principles with applied examples from the recent literature. We hope this book motivates readers to develop their own models for diseases of interest, expanding on the model frameworks given here.

1.1. TYPES OF DISEASE

The Oxford English Dictionary defines a disease as "a condition of the body, or of some part or organ of the body, in which its functions are disturbed or deranged; a morbid physical condition; a departure from the state of health, especially when caused by structural change." This definition encompasses a wide range of ailments from AIDS to arthritis, from the common cold to cancer. The fine-scale classification of diseases varies drastically between different scientific disciplines. Medical doctors and veterinary clinicians, for example, are primarily interested in treating human patients or animals and, as such, are most concerned about the infection's pathophysiology (affecting, for example, the central nervous system) or clinical symptoms (for example, secretory diarrhea). Microbiologists, on the other hand, focus on the natural history of the causative organism: What is the etiologicalagent (avirus, bacterium, protozoan, fungus, orprion)? and what are the ideal conditions for its growth? Finally, epidemiologists are most interested in features that determine patterns of disease and its transmission.

In general terms, we may organize diseases according to several overlapping classifications (Figure 1.1). Diseases can be either infectious or noninfectious. Infectious diseases (such as influenza) can be passed between individuals, whereas noninfectious diseases (such as arthritis) developover an individual's lifespan. The epidemiology of noninfectious diseases is primarily a study of risk factors associated with the chance of developing the disease (for example, the increased risk of lung cancer attributable to smoking). In contrast, the primary risk factor for catching an infectious disease is the presence of infectious cases in the local population-this tenet is reflected in all the mathematical models presented in this book. These two categories, infectious and noninfectious, are not necessarily mutually exclusive. Infection with the human papillomavirus (HPV), for example, is firmly associated with (although not necessary for developing) cervical cancer, thus bridging the two fields. This book focuses on infectious diseases, where models have great predictive power at the population scale and over relatively short time scales.

Infectious diseases can be further subdivided (Figure 1.1). The infecting pathogen can be either a microparasite (hatched in diagram) or a macroparasite. Microparasites, as the same suggests, are small (usually single-cell organisms) and are either viruses, bacteria, protoza, or prions; macroparasites are any larger form of pathogen and include helminths and flukes. Although the biological distinction between these two groups of organisms is clear, from a modeling perspective the boundaries are less well defined. In general, microparasitic infections develop rapidly from a small number of infecting particles so the internal dynamics of the pathogen within the host can often be safely ignored. As a result, we are not interested in the precise abundance of pathogens within the host; instead we focus on the host's infection status. In contrast, macroparasites such as helminths have a complex life cycle with in the host which often needs to be modeled explicitly. In addition, the worm burden, or the number of parasites within the host, represents an important contributing factor to pathogenicity and disease transmission. We focus in this book on microparasites, where extensive long-term data and a good mechanistic understanding of the transmission dynamics have led to a wealth of well-parameterized models.

Infectious diseases (both macro-and microparasitic) can also be subdivided into two further categories (Figure 1.1), depending on whether transmission of infection is direct (shaded gray) or indirect. Direct transmission is when infection is caught by close contact with an infectious individual. The great majority of microparasitic diseases, such as influenza, measles, and HIV, are directly transmitted, although there are exceptions such as cholera, which is waterborne. Generally, directly transmitted pathogens do not survive for long outside the host organism. In contrast, indirectly transmitted parasites are passed between hosts via the environment; most macroparasitic diseases, such as those caused by helminths and schistosomes, are indirectly transmitted, spending part of their life cycle outside of their hosts. In addition, there is a class of diseases where transmission is via a secondary host or vector, usually insects such as mosquitoes, tsetseflies, orticks. However, this transmission route can be considered as two sequential direct transmission events, from the primary host to the insect and then from the insect to another primary host.

The models and diseases of this book are focused toward the study of directly transmitted, microparasitic infectious diseases. As such, this subset represents only a fraction of the whole field of epidemiological modeling and analysis, but one in which major advances have occurred over recent decades.

Worldwide there are about 1,415 known human pathogens of which 217 (15%) are viruses or prions and 518 (38%) are bacteria or rickettsia; hence around 53% are micro-parasites (Cleaveland et al. 2001). Of these pathogens, 868 (61%) are zoonotic and can therefore be transmitted from animals to humans. Around 616 pathogens of domestic livestock are known, of which around 18% are viral and 25% bacterial. However, if we restrict our attention to the 70 pathogens listed by the Office International des Epizooties (which contain the most prominent and infectious livestock diseases), we find that 77% are microparasites (Cleaveland et al. 2001). The lower number of known livestock pathogens compared to human pathogens probably reflects to some degree our natural anthropocentric bias. Similarly, very few infectious diseases of wildlife are known or studied in any detail, and yet wildlife reservoirs may be important sources of novel emerging human infections. It is therefore clear that the study of microparasitic infectious diseases encompasses a huge variety of hosts and diseases.

1.2. CHARACTERIZATION OF DISEASES

The progress of an infectious microparasitic disease is defined qualitatively in terms of the level of pathogen within the host, which in turn is determined by the growth rate of the pathogen and the interaction between the pathogen and the host's immune response. Figure 1.2...

Details zur Ausgabe

• Verlag: PRINCETON UNIV PR
• Erscheinungsdatum: 2007
• Sprache: Englisch
• ISBN 10: 0691116172
• ISBN 13: 9780691116174
• Einband: Gebundene Ausgabe
• Anzahl der Seiten: 384
• Kontakt zum Hersteller: Nicht verfügbar
• Verantwortliche Person: Nicht verfügbar