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How understanding our genetic imperfections can change our view of evolution and enrich what it means to be human
If we start with the presumption that evolution is a constantly improving process, some aspects of our evolution just do not make sense. We have a high rate of genetic diseases, for example, and much of our DNA seems to be pointless. In The Evolution of Imperfection, Laurence Hurst explores our apparently rotten genetic luck.
Hurst, a leading authority on evolution and genetics, argues that our evolutionary imperfections proceed directly from two features: the difficulties of pregnancy and the fact that historically there are relatively few of us. In pregnancy, natural selection can favor chromosomes that kill embryos in species (including ours) that continuously receive resources from the mother. Most fertilized eggs don’t make it, and incompatibilities between the fetus and mother can lead to lethal disorders of pregnancy. The historically small population size enhances the role of chance, which in turn leads to both accumulation of unnecessary DNA and more mutation.
So what can save us? One answer may lie in genetic medicine, which has given us therapies that make killer conditions preventable and even curable.
Hurst suggests that our seeming imperfections could be the key to a new way to understand evolution itself. Looking at circumstances that seem to defy explanation, we might come to a richer understanding of how evolution really works, and what it means to be human.
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Laurence D. Hurst is professor of evolutionary genetics in the Milner Centre for Evolution at the University of Bath. His research on how genetic systems evolve, and the application of this knowledge to medicine, has been recognized with national and international prizes and fellowships.
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Hardback. Zustand: New. How understanding our genetic imperfections can change our view of evolution and enrich what it means to be humanIf we start with the presumption that evolution is a constantly improving process, some aspects of our evolution just do not make sense. We have a high rate of genetic diseases, for example, and much of our DNA seems to be pointless. In The Evolution of Imperfection, Laurence Hurst explores our apparently rotten genetic luck.Hurst, a leading authority on evolution and genetics, argues that our evolutionary imperfections proceed directly from two features: the difficulties of pregnancy and the fact that historically there are relatively few of us. In pregnancy, natural selection can favor chromosomes that kill embryos in species (including ours) that continuously receive resources from the mother. Most fertilized eggs don't make it, and incompatibilities between the fetus and mother can lead to lethal disorders of pregnancy. The historically small population size enhances the role of chance, which in turn leads to both accumulation of unnecessary DNA and more mutation.So what can save us? One answer may lie in genetic medicine, which has given us therapies that make killer conditions preventable and even curable.Hurst suggests that our seeming imperfections could be the key to a new way to understand evolution itself. Looking at circumstances that seem to defy explanation, we might come to a richer understanding of how evolution really works, and what it means to be human. Bestandsnummer des Verkäufers LU-9780691247397
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The Evolution of Imperfection : The Science of Why We Aren't and Can't Be Perfect
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Princeton University Press Apr 2025, 2025
ISBN 10: 0691247390
ISBN 13: 9780691247397
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Buch. Zustand: Neu. Neuware - 'This book uncovers the ways natural selection leads to imperfection in humans and the implications of this for our understanding of how evolution works and human biology and health. The simplest version of evolution frames it as a gradual process that leads to constant improvement. This view holds that natural selection drives toward 'perfection.' Mutations in an organism's genome either harm or help its ability to reproduce; harmful ones don't last while beneficial ones are passed on and spread throughout a population. As Laurence Hurst argues in this book, the reality is far more complicated. This is particularly true for humans at the level of our DNA. Why, for example do we need so many sperm to fertilize one egg Or why do we have a high rate of genetic disease And why does much of our DNA appear to be pointless These imperfections do not make sense when we assume that evolution is a constantly improving process, yet the more scientists study our genome the more they see things that look like imperfections. How, then, are they explained After carefully introducing readers to what he means by perfection and imperfection and providing basic information about DNA, Hurst provides evidence for why the human genome retains imperfections. He argues that our small populations, high mutation rates, and mode of reproduction leave us vulnerable to all sorts of problems. In dissecting the evolution of our imperfection, Hurst illuminates what scientists are learning about the human genome and why it seems to cause so many issues despite our success as a species. Finally, despite what we might call our 'rotten lot,' evolutionarily speaking, we have our big brains and medicine to combat genetic disease and, at the end of the book, Hurst reviews what scientists are learning about curing genetically based diseases'. Bestandsnummer des Verkäufers 9780691247397
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Hardback. Zustand: New. How understanding our genetic imperfections can change our view of evolution and enrich what it means to be humanIf we start with the presumption that evolution is a constantly improving process, some aspects of our evolution just do not make sense. We have a high rate of genetic diseases, for example, and much of our DNA seems to be pointless. In The Evolution of Imperfection, Laurence Hurst explores our apparently rotten genetic luck.Hurst, a leading authority on evolution and genetics, argues that our evolutionary imperfections proceed directly from two features: the difficulties of pregnancy and the fact that historically there are relatively few of us. In pregnancy, natural selection can favor chromosomes that kill embryos in species (including ours) that continuously receive resources from the mother. Most fertilized eggs don't make it, and incompatibilities between the fetus and mother can lead to lethal disorders of pregnancy. The historically small population size enhances the role of chance, which in turn leads to both accumulation of unnecessary DNA and more mutation.So what can save us? One answer may lie in genetic medicine, which has given us therapies that make killer conditions preventable and even curable.Hurst suggests that our seeming imperfections could be the key to a new way to understand evolution itself. Looking at circumstances that seem to defy explanation, we might come to a richer understanding of how evolution really works, and what it means to be human. Bestandsnummer des Verkäufers LU-9780691247397
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