Interindividual Variability in Human Drug Metabolism - Hardcover

Hardcover

ISBN 10: 0748408649 ISBN 13: 9780748408641

Verlag: Taylor & Francis Ltd, 2001

Inhaltsangabe

The book provides an exhaustive, authoritative and updated review on the interindividual variability in drug metabolism in humans. Four chapters address the general background: genetic factors causing variability, interethnic variability, environmental factors and developing and ageing as sources of variability. Six chapters address variability of drug metabolism in vivo: variability of psychotropic drugs, antiepileptic drugs, the dopamine precursor levodopa, cardiovascular active drugs and anti HIV drugs. Seven chapters address the interindividual variability of the main drug metabolizing enzymes: CYP-450s, acetyltransferases, glucuronosyl transferase, methyl transferases, sulfotransferases and glutathione transferases in human liver and extrahepatic tissues. A separate chapter discusses the prediction of drug interaction.

Comprehensive in coverage, and with contributions from the leading international experts, this book is essential reading for researchers from both academia and the pharmaceutical industry. Advanced undergraduates and postgraduates in pharmacology, clinical pharmacology, toxicology, biochemistry and epidemiology who are interested in drug metabolism will also find this an indispensable resource.

Über diesen Titel

Über die Autorin bzw. den Autor

Gian Maria Pacifici, Olavi Pelkonen

Details zur Ausgabe

• Verlag: Taylor & Francis Ltd
• Erscheinungsdatum: 2001
• Sprache: Englisch
• ISBN 10: 0748408649
• ISBN 13: 9780748408641
• Einband: Gebundene Ausgabe
• Anzahl der Seiten: 400
• Herausgeber: Pacifici Gian Maria, Pelkonen O., Pelkonen R. O.
• Kontakt zum Hersteller: Nicht verfügbar
• Verantwortliche Person: Taylor & Francis Verlag GmbH; GPSR@taylorandfrancis.com; ; Kaufingerstraße 24, 80331 München, Germany; München; Deutschland