Introduction to Cellular Signal Transduction: An Introduction (Hormones in Health and Disease) - Hardcover

Hardcover

ISBN 10: 0817639829 ISBN 13: 9780817639822

Verlag: Birkhäuser, 1999

Inhaltsangabe

Foreword * Contributors * Overview by Ari Sitaramayya * Cell Surface Receptors: Mechanisms of Signaling and Inactivation * Heterotrimeric G-proteins: Structure, Regulation and Signaling Mechanisms * Ras and Rho-Related Small Molecular Weight G-proteins: Structure and Signaling Mechanisms * Cyclic Nucleotides: Synthesis by Adenylyl and Guanylyl Cyclases * Phospholipases: Generation of Lipid-Derived Second Messengers * Cyclic Nucleotide Phosphodiesterases: Structure and Functional Aspects * Nitric Oxide: Synthesis and Intracellular Actions * Ionic Channels Mediating Sensory Transduction * Bits for an Organic Microprocessor: Protein Phosphorylation/Dephosphorylation * Defects in Signal Transduction Proteins Leading to Disease * Intracellular Messengers in Drug Addiction * Keyword Index

Über diesen Titel

Reseña del editor

The mechanism of information transfer between cells is the subject of Introduction to Signal Transduction. Until recently various aspects of signaling by hormones were studied (and taught) under the subject of endocrinology, and signaling by neurotransmitters was the subject of neurochemistry. With growing awareness of the many similarities between hormonal and neurotransmitter signalling, recent years have witnessed the emergence of Signal Transduction as an independent discipline covering all aspects of information transfer between cells irrespective of the nature and source of the signals. This book is designed for senior undergraduate/graduate-level students interested in a basic understanding of the major participants in the cellular Signal Transduction pathways. The book covers the major topics in Signal Transduction: receptors, which recognize the signals at the cell surface; G-proteins, which transduce the signals; and adenylate cyclases, guanlate cyclases, and phospholipases, which generate second messengers. Chapters also focus on ion channels, phosphodiesterases, protein kinases, phosphoprotein phosphatases and nitric oxide, which participate in the cellular response to signals; the health consequences of defects in Signal Transduction proteins; and the central role Signal Transduction plays in drug abuse. The book is suitable for an introductory course in Signal Transduction as well as for self-study and review. It is recommended for biology and medical students, as well as for interdisciplinary science majors and pharmaceutical researchers.

Reseña del editor

The mechanism of information transfer between cells is the subject of this text. In the past, aspects of this field were the domain of different disciplines, including endocrinology, neurochemistry, and pharmacology. However, in recent years, signal transduction has emerged as an independent discipline. This book covers the major topics in signal transduction: receptors which recognize the signal molecules at the cell surface; G-proteins which induce the signals; and adenylate cyclases, granylate cyclases, and prospholipases which generate the second messenger. The discussion focuses on ion channels, prosphodiesterases and protein kinases, which participate in the ultimate cellular response to signals, the health consequences of defects in signal transduction proteins, and the central role signal transduction plays in drug abuse. This volume is designed to be a reference source for investigators in the field, and is aimed at students interested in an overall understanding of the concepts involved in cell signalling. The topics are covered with the goal of preparing the reader for an in-depth examination.

Details zur Ausgabe

• Verlag: Birkhäuser
• Erscheinungsdatum: 1999
• Sprache: Englisch
• ISBN 10: 0817639829
• ISBN 13: 9780817639822
• Einband: Tapa dura
• Anzahl der Seiten: 328
• Herausgeber: Sitaramayya Ari
• Kontakt zum Hersteller: Nicht verfügbar
• Verantwortliche Person: Nicht verfügbar