Hematopoietic Stem Cell Transplantation - Hardcover

 
9780824702731: Hematopoietic Stem Cell Transplantation
Hardcover
ISBN 10: 0824702735 ISBN 13: 9780824702731
Verlag: CRC Press Inc, 2000

Inhaltsangabe

This book integrates recent advances in molecular and cell biology of hematopoietic stem cells (HSC) with developments in clinical research in stem cell-based therapy-providing an up-to-date review of novel cytokines and cellular components; animal models; cell preparation, selection, and collection; minimal residual disease and purging; expansion of progenitor cells; allogeneic and autologous transplantation; cellular gene and immunotherapy; and more.
Examines key areas for treatment with HSC, including ambulatory care and monitoring, regimen-related toxicities, immunodeficiency and immunization, infection, chronic graft-versus-host and disease, secondary malignancies, and long-term quality of life.
Covering stem cell pool regulation and the complex interplay of extrinsic and intrinsic events, Hematopoietic Stem Cell Transplantation

  • summarizes current understanding and development of clinical allogeneic HSC transplantation
  • discusses the use of allogeneic transplantations with reduced conditioning regimen or mini-transplantation
  • considers various strategies for mobilization of HSCs from peripheral blood (PB) of normal donors
  • details detection of bone marrow contamination by tumor cells and removal procedures
  • focuses on efforts to increase the ex vivo transduction efficiency of human HSCs with retroviral vectors
  • explores the effects of growth factor administration and leukapheresis on PB stem cell donors
  • shows the impact of CD34+ cell isolation and the relevance of expansion of HSC from bone marrow for clinical use
  • reveals how minimal residue disease detection assays are crucial for tracking the clinical significance of infused tumor cells
  • employs automated fluorescence image cytometry to study early HSC behavior following seeding
    Incorporating contributions from over 90 researchers who cite more than 2180 references to encourage continued study,

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    Über die Autorin bzw. den Autor

    Anthony D. Ho, Rainer Haas, Richard E. Champlin

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    Verlag
    CRC Press Inc
    Erscheinungsdatum
    2000
    Sprache
    Englisch
    ISBN 10 
    0824702735
    ISBN 13 
    9780824702731
    Einband
    Gebundene Ausgabe
    Anzahl der Seiten
    604
    Herausgeber
    Ho Anthony D., Haas Rainer, Champlin Richard E.
    Kontakt zum Hersteller
    Nicht verfügbar
    Verantwortliche Person
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