This volume reviews a series of different publications dealing with orotic acid. Orotic acid was isolated from cow's milk 75 years ago by Biscaro and Belloni in Italy. Fifty years later again Italian scientists described the growth-promoting activity of orotic acid in vitamin B -deficient animals. 12 Orotic acid is the precursor of pyrimidine nucleotides which are involved in many biochemical reactions: UTP and CTP, as substrates for RNA polymerase, and UDP sugars, as substrates for carbohydrate containing macromolecules, e.g. glycogen, glycoproteins and glycolipids. The biosynthesis of these pyrimidines is well regulated. Disturbance of the biosynthetic pathway or trapping of individual pyrimidine nucleotides may lead to severe metabolic and structural alterations of cells. Synthesis, biochemical aspects and physiological role are reviewed in nine chapters. In the last two decades increasing interest in orotic acid came from several studies showing protective or therapeutic or beneficial effects of this compound in different kinds of organ injuries: various forms of hepatic insufficiency, myocardial infarction, encephalopathy, memorization pro- cesses, mentioned in Chapters 8 and 9. At the end of this overview a Bibliography in an alphabetical order with 673 references may give further insight in this topic.
Die Inhaltsangabe kann sich auf eine andere Ausgabe dieses Titels beziehen.
This volume reviews a series of different publications dealing with orotic acid. Orotic acid was isolated from cow's milk 75 years ago by Biscaro and Belloni in Italy. Fifty years later again Italian scientists described the growth-promoting activity of orotic acid in vitamin B -deficient animals. 12 Orotic acid is the precursor of pyrimidine nucleotides which are involved in many biochemical reactions: UTP and CTP, as substrates for RNA polymerase, and UDP sugars, as substrates for carbohydrate containing macromolecules, e.g. glycogen, glycoproteins and glycolipids. The biosynthesis of these pyrimidines is well regulated. Disturbance of the biosynthetic pathway or trapping of individual pyrimidine nucleotides may lead to severe metabolic and structural alterations of cells. Synthesis, biochemical aspects and physiological role are reviewed in nine chapters. In the last two decades increasing interest in orotic acid came from several studies showing protective or therapeutic or beneficial effects of this compound in different kinds of organ injuries: various forms of hepatic insufficiency, myocardial infarction, encephalopathy, memorization pro cesses, mentioned in Chapters 8 and 9. At the end of this overview a Bibliography in an alphabetical order with 673 references may give further insight in this topic.
„Über diesen Titel“ kann sich auf eine andere Ausgabe dieses Titels beziehen.
EUR 2,30 für den Versand innerhalb von/der Deutschland
Versandziele, Kosten & DauerAnbieter: Antiquariat Bücherlöwe, Braunschweig, Deutschland
Pappe/Schutzum., englisch, vii, 118 S., 24 X 16 cm, Guter Zustand., 2. Bestandsnummer des Verkäufers B 299
Anzahl: 1 verfügbar
Anbieter: Stella & Rose's Books, PBFA, Tintern, MON, Vereinigtes Königreich
Hardback. Zustand: Very Good. Zustand des Schutzumschlags: Very Good. First edition. 1st 1980. Very good condition in a nearly fine dustwrapper. This volume reviews a series of different publications dealing with orotic acid. Brown cloth boards, gilt title to spine. vii and 118 pages. Top & tail of spine lightly shelf-worn. Couple of minor marks to lower edge of boards. Pencil erasure mark to front endpaper. Small library stamp to title page but no other library markings seen. Else contents clean. Orange dustwrapper is lightly scuffed, remains of small label to front flap. Packaged with care and promptly dispatched! Bestandsnummer des Verkäufers 2121105
Anzahl: 1 verfügbar