Metal Carcinogenesis Testing: Principles and in Vitro Methods (Biological Methods) - Hardcover

Costa, Max

Hardcover

ISBN 10: 0896030172 ISBN 13: 9780896030176

Verlag: Humana Press, 1980

Inhaltsangabe

Metal Carcinogenesis Testing explains fundamental principles of metal carcinogenesis as they are currently understood, and provides detailed practical descriptions of rapid and inexpensive in vitro assay methodology presently in use for the detection of potentially carci­ nogenic metals and their compounds. Mounting experimental evidence has suggested that a number of metals and their compounds are potentially carcinogenic to humans. Since humans are exposed to these potentially carcinogenic metals in industrial situations and through environmental pollution, it is essential that experimental protocols be available to identify the specific metal compounds that are potentially carcinogenic. This book affords a thorough description of the various carcinogenesis test systems available for metals, centering on those that are rapid, inexpensive, and most reliable. The principles are discussed at the level of human exposure, of animal studies, and of research in vitro. Additionally, the molecular mechanisms of metal-induced cancer are considered at each ofthese three levels.In large part, the emphasis rests on the use of in vitro, biochemical and bacterial studies, including tissue culture, because these methods are the basis of the rapid and inexpensive screening of potentially carcinogenic substances.

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Reseña del editor

This text offers a comprehensive treatment of the fundamental biological, chemical and epidemiological principles of metal carcinogenesis and its assay as these are presently understood. It addresses problems of human exposure, the induction of tumors in experimental animals, and the effects of metal on "in vitro" systems. This book should be of interest to pharmacologists, toxicologists, epidemiologists, biologist, pathologist, industrial hygienists and those needing actively to assay metals and their compounds for carcinogenicity.

Details zur Ausgabe

• Verlag: Humana Press
• Erscheinungsdatum: 1980
• Sprache: Englisch
• ISBN 10: 0896030172
• ISBN 13: 9780896030176
• Einband: Tapa dura
• Anzahl der Seiten: 188
• Kontakt zum Hersteller: Nicht verfügbar
• Verantwortliche Person: Nicht verfügbar