Trace Elements, Micronutrients, and Free Radicals (Contemporary Issues in Biomedicine, Ethics, and Society) - Hardcover

Dreosti, Ivor E.

Hardcover

ISBN 10: 0896031888 ISBN 13: 9780896031883

Verlag: Humana Press, 1991

Inhaltsangabe

ITISONLYRECENTLY THATTHE NATURALOCCURRENCEOFFREE RADICALSIN BIOLOGICAL TISSUE HAS BECOME WIDELY ACCEPTED, AND THAT THE SUSPIÐ CION WITH WHICH BIOLOGISTS PREVIOUSLY VIEWED THE FREE RADICALS OF RADIATIONCHEMISTRYHAS BEENPLACEDIN A BROADERPERSPECTIVE. NOW, OXYGEN-DERIVED FREE RADICALS ARE CONSIDERED RESPECTABLE BIOCHEMIÐ CAL INTERMEDIATES, GIVEN ALWAYS THE CAVEAT THAT UNWANTED TISSUE DAMAGE MAY ARISE IF THESE ACTIVE SPECIES ARE PRODUCED IN SUCH ABUNDANCE THAT THEY OVERWHELM THE NATURAL ANTIOXIDANT AND FREEÐ RADICAL DEFENSE MECHANISMS, OR IF THESE SYSTEMS HAVE BECOME HYPOEFFECTIVE. MANY FACTORS, INCLUDING SEVERAL DIETARY MANIPULAÐ TIONS, CAN LEAD TOELEVATEDPRODUCTIONOFSUPEROXIDE AND MAY RESULT IN FREE RADICAL OVERLOAD, WHEREAS A DEFICIENCY OF THOSE MICRONUTRIÐ ENTS ASSOCIATED WITH THE ANTIOXIDANT DEFENSE MEC.HANISMS MAY REÐ SULT IN SUBSTANTIALLY DIMINISHED ANTIOXIDANT CAPACITY. BY NOW, ANTIOXIDANTS HAVE BECOME A HOUSEHOLD WORD AND ALÐ MOST EVERYONE IS AWARE OF THEIR IMPONANCE IN PROTECTING THE BODY AGAINST ATTACK BY ACTIVE OXYGEN SPECIES. INDEED, IT IS A PARADOX OF NATURE THAT OXYGEN, WHICH IS SO ESSENTIAL TO SUSTAIN AEROBIC LIFE, ULÐ TIMATELY CONTRIBUTES TO ITS DESTRUCTION. NOT SURPRISINGLY, RECOGNIÐ TION OFTHIS DILEMMA HAS GENERATED A SPATE OFANTIOXIDANT STRATEGIES INTENDED TO REDUCE THE RISK OF TISSUE DAMAGE BY RAMPANT OXYGEN RADICALS, SOME SADLY BASED LESS ON SCIENCE THAN ON SPECULATION.

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Críticas:

...Highly recommend[ed].-Journal of Medicinal Chemistry

Reseña del editor:

Itisonlyrecently thatthe naturaloccurrenceoffree radicalsin biological tissue has become widely accepted, and that the suspi­ cion with which biologists previously viewed the free radicals of radiationchemistryhas beenplacedin a broaderperspective. Now, oxygen-derived free radicals are considered respectable biochemi­ cal intermediates, given always the caveat that unwanted tissue damage may arise if these active species are produced in such abundance that they overwhelm the natural antioxidant and free­ radical defense mechanisms, or if these systems have become hypoeffective. Many factors, including several dietary manipula­ tions, can lead toelevatedproductionofsuperoxide and may result in free radical overload, whereas a deficiency of those micronutri­ ents associated with the antioxidant defense mec.hanisms may re­ sult in substantially diminished antioxidant capacity. By now, antioxidants have become a household word and al­ most everyone is aware of their imponance in protecting the body against attack by active oxygen species. Indeed, it is a paradox of nature that oxygen, which is so essential to sustain aerobic life, ul­ timately contributes to its destruction. Not surprisingly, recogni­ tion ofthis dilemma has generated a spate ofantioxidant strategies intended to reduce the risk of tissue damage by rampant oxygen radicals, some sadly based less on science than on speculation.

Über diese Auflage

• Verlag: Humana Press
• Erscheinungsdatum: 1991
• ISBN 10: 0896031888
• ISBN 13: 9780896031883
• Einband: Tapa dura
• Anzahl der Seiten: 244