Protein Structure Prediction: Methods and Protocols: v. 143 (Methods in Molecular Biology) - Hardcover

Webster, David

Hardcover

ISBN 10: 0896036375 ISBN 13: 9780896036376

Verlag: Humana Press Inc., 2000

Inhaltsangabe

Protein Structure Prediction is aimed at the novice, as well as experienced researchers in this field who all need detailed information that combines theoretical and practical aspects. Its major intent is to include information relevant to the daily work of a research scientist, but may not always be obvious in the original scientific literature. Covers many aspects, from sequence analysis, which is often the starting point for algorithms, through secondary and tertiary methods, to the prediction of docked complexes, which are essential to fully understand biological function. Also covers the development of suitable folding potentials essential for many of the methods presented in the volume. Expert knowledge of protein structure prediction from the contributors is applied to many disciplines, such as the identification of domains and motifs; the comparative modeling of proteins; and ab initio approaches to protein loop, side chain, and protein prediction. This is an essential resource to both the expert and non-expert in the field, as the need for accurate and useful predicted structures continues to increase due to advances in technology and the understanding of the principles of protein structure folding.

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Críticas

The organization of this book is excellent. Eighteen chapters lead the reader through the entire process. Many of the authors are, in fact, the developers of some commonly used methods and offer a first-hand introduction to their software. The emphasis is on providing a practical handbook most chapters contain detailed tutorials and worked-through examples that give a real-life flavor to the explanations. - Journal of American Chemical Society The book is a collection of 18 review articles, many written by distinguished experts in their field, providing an overview of the major aspects of protein structure prediction. About half of the articles deal with specific software packages, many of which are free to academic users, where the author of the software discussed. a useful reference to address for anyone thinking of dipping their toes into this exciting field. - Biochemistry and Molecular Biology Education

Reseña del editor

World-class investigators detail their most successful methods-and the theory behind them-for delineating the shape, form, and function of proteins. The protocols range from basic to advanced and include sequence alignment, the prediction of transmembrane protein structure, and the development of suitable folding potentials. There are also techniques for receptor site prediction, the identification of motifs and domains, the comparative modeling of proteins, the docking of peptides and ligands, and ab initio approaches to protein loop and side-chain prediction. Comprehensive, accessible, and highly practical, Protein Structure Prediction: Methods and Protocols offers protein researchers, structural biologists, and other investigators a critical synthesis of the latest research results, as well as the vital guidance needed to understand the structure and interaction of proteins and peptides.

Details zur Ausgabe

• Verlag: Humana Press Inc.
• Erscheinungsdatum: 2000
• Sprache: Englisch
• ISBN 10: 0896036375
• ISBN 13: 9780896036376
• Einband: Tapa dura
• Anzahl der Seiten: 300
• Kontakt zum Hersteller: Nicht verfügbar
• Verantwortliche Person: Nicht verfügbar