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Cytochrome P450: In Vitro Methods and Protocols (Methods in Pharmacology and Toxicology) - Hardcover

 
9781071615416: Cytochrome P450: In Vitro Methods and Protocols (Methods in Pharmacology and Toxicology)
Hardcover
ISBN 10: 1071615416 ISBN 13: 9781071615416
Verlag: Humana, 2021

Inhaltsangabe

This collection explores detailed experimental protocols necessary for setting up a variety of in vitro cytochrome P450 (CYP) assays that are vital in selecting drug candidates in a drug discovery pipeline. Major factors affecting drug metabolism include CYP expression levels, kinetic parameters for individual CYP enzymes, CYP inhibition and induction, time-dependent inhibition (TDI), CYP stability, non-CYP stability, UDP-glucuronosyltransferases (UGT) stability, excretion mechanisms, and drug-drug interactions (DDI), all addressed in this volume. Written for the Methods in Pharmacology and Toxicology series, chapters include helpful background information on the in vitro assay, a list of all the materials, reagents, and equipment necessary to carry out the assay, a step-by-step protocol, notes containing common and unexpected experimental problems in the assay, as well as references containing important supplementary reading. 


Authoritativeand practical, Cytochrome P450: In Vitro Methods and Protocols serves as a key guide for researchers in the area of discovery and development of new medicines. 

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This collection explores detailed experimental protocols necessary for setting up a variety of in vitro cytochrome P450 (CYP) assays that are vital in selecting drug candidates in a drug discovery pipeline. Major factors affecting drug metabolism include CYP expression levels, kinetic parameters for individual CYP enzymes, CYP inhibition and induction, time-dependent inhibition (TDI), CYP stability, non-CYP stability, UDP-glucuronosyltransferases (UGT) stability, excretion mechanisms, and drug-drug interactions (DDI), all addressed in this volume. Written for the Methods in Pharmacology and Toxicology series, chapters include helpful background information on the in vitro assay, a list of all the materials, reagents, and equipment necessary to carry out the assay, a step-by-step protocol, notes containing common and unexpected experimental problems in the assay, as well as references containing important supplementary reading. 


Authoritativeand practical, Cytochrome P450: In Vitro Methods and Protocols serves as a key guide for researchers in the area of discovery and development of new medicines. 

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Verlag
Humana
Erscheinungsdatum
2021
Sprache
Englisch
ISBN 10 
1071615416
ISBN 13 
9781071615416
Einband
Gebundene Ausgabe
Auflage
1
Anzahl der Seiten
390
Herausgeber
Yan Zhengyin, Caldwell Gary W.
Kontakt zum Hersteller
preigu GmbH & Co. KG
mail@preigu.de

Lengericher Landstr. 19
Osnabrück
Niedersachsen
49078
Deutschland

Weitere beliebte Ausgaben desselben Titels

9781071615447: Cytochrome P450: In Vitro Methods and Protocols (Methods in Pharmacology and Toxicology)

Vorgestellte Ausgabe

ISBN 10:  1071615440 ISBN 13:  9781071615447
Verlag: Humana, 2022
Softcover