Hedgehog Signaling: Methods and Protocols (Methods in Molecular Biology, Band 2374) - Softcover

 
9781071617038: Hedgehog Signaling: Methods and Protocols (Methods in Molecular Biology, Band 2374)
Softcover
ISBN 10: 1071617036 ISBN 13: 9781071617038
Verlag: Humana, 2022

Inhaltsangabe

This detailed book explores the technical breakthroughs with biophysical and cell biological approaches that have advanced the study of molecular mechanisms underlying the generation and transduction of the hedgehog (HH) signal, indicating the important role of sterols in this pathway. Within its pages, the volume examines techniques involving several key protein components in this pathway, including HH, the signaling ligand; Dispatched, a HH secretion regulator; Patched, the receptor of HH; Smoothened, the signal transducer used to transduce the HH signal across the plasma membrane; and GLI, the transcription factor to turn on HH target genes. Written in the highly successful Methods in Molecular Biology series format, chapters feature introductions to their respective topics, lists of the necessary materials and reagents, step-by-step readily reproducible laboratory protocols, as well as tips on troubleshooting and avoiding known pitfalls. 


Authoritative and practical, Hedgehog Signaling: Methods and Protocols provides researchers in clinical and basic science with a fresh and reliable reference for analyzing HH signal transduction through cell biological, biochemical, and biophysical approaches.

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This detailed book explores the technical breakthroughs with biophysical and cell biological approaches that have advanced the study of molecular mechanisms underlying the generation and transduction of the hedgehog (HH) signal, indicating the important role of sterols in this pathway. Within its pages, the volume examines techniques involving several key protein components in this pathway, including HH, the signaling ligand; Dispatched, a HH secretion regulator; Patched, the receptor of HH; Smoothened, the signal transducer used to transduce the HH signal across the plasma membrane; and GLI, the transcription factor to turn on HH target genes. Written in the highly successful Methods in Molecular Biology series format, chapters feature introductions to their respective topics, lists of the necessary materials and reagents, step-by-step readily reproducible laboratory protocols, as well as tips on troubleshooting and avoiding known pitfalls. 


Authoritative and practical, Hedgehog Signaling: Methods and Protocols provides researchers in clinical and basic science with a fresh and reliable reference for analyzing HH signal transduction through cell biological, biochemical, and biophysical approaches.

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Verlag
Humana
Erscheinungsdatum
2022
Sprache
Englisch
ISBN 10 
1071617036
ISBN 13 
9781071617038
Einband
Taschenbuch
Auflage
1
Anzahl der Seiten
256
Herausgeber
Li Xiaochun
Kontakt zum Hersteller
Springer-Verlag GmbH
customerservice@springernature.com

Tiergartenstraße 17
Heidelberg
Baden-Württemberg
69121
Deutschland

Weitere beliebte Ausgaben desselben Titels

9781071617007: Hedgehog Signaling: Methods and Protocols (Methods in Molecular Biology, 2374, Band 2374)

Vorgestellte Ausgabe

ISBN 10:  1071617001 ISBN 13:  9781071617007
Verlag: Humana, 2021
Hardcover