Interpretation of MS-MS Mass Spectra of Drugs and Pesticides (Wiley Series on Mass Spectrometry) - Hardcover

Niessen, Wilfried M. A.

Hardcover

ISBN 10: 1118500180 ISBN 13: 9781118500187

Verlag: Wiley, 2017

Inhaltsangabe

PROVIDES COMPREHENSIVE COVERAGE OF THE INTERPRETATION OF LC MS MS MASS SPECTRA OF 1300 DRUGS AND PESTICIDES PROVIDES A GENERAL DISCUSSION ON THE FRAGMENTATION OF EVEN–ELECTRON IONS (PROTONATED AND DEPROTONATED MOLECULES) IN BOTH POSITIVE–ION AND NEGATIVE–ION MODES   THIS IS THE REFERENCE BOOK FOR THE INTERPRETATION OF MS MS MASS SPECTRA OF SMALL ORGANIC MOLECULES  COVERS RELATED THERAPEUTIC CLASSES OF COMPOUNDS SUCH AS DRUGS FOR CARDIOVASCULAR DISEASES, PSYCHOTROPIC COMPOUNDS, DRUGS OF ABUSE AND DESIGNER DRUGS, ANTIMICROBIALS, AMONG MANY OTHERS COVERS GENERAL FRAGMENTATION RULE AS WELL AS SPECIFIC FRAGMENTATION PATHWAYS FOR MANY CHEMICAL FUNCTIONAL GROUPS GIVES AN INTRODUCTION TO MS TECHNOLOGY, MASS SPECTRAL TERMINOLOGY, INFORMATION CONTAINED IN MASS SPECTRA, AND TO THE IDENTIFICATION STRATEGIES USED FOR DIFFERENT TYPES OF UNKNOWNS

Über diesen Titel

Críticas:

'The present book is a needed contribution in the field of tandem mass spectrometry of low molecular weight compounds in particular for the fragmentation of even electron ions formed by popular soft ionization techniques such as electrospray. The five chapters provide comprehensive insights of MS/MS spectra acquisition, characterization and interpretation. It is a unique resource to any scientist using LCMS/ MS for qualitative and quantitative analysis of drugs and pesticides.' Analytical and Bioanalytical Chemistry, November 2017

Reseña del editor:

Mass spectrometry (MS) is an indispensable tool in structure elucidation and quantitative analysis of a wide variety of compound classes, such as drugs and pesticides. For this purpose, MS is mostly used in combination with either gas or liquid chromatography (GC-MS or LC-MS). In compound identification by LC-MS, extensive knowledge is needed on the fragmentation of even-electron ions in tandem mass spectrometry (MS-MS). Interpretation of MS-MS Mass Spectra of Drugs and Pesticides details all of the relevant information on the fragmentation of drugs and pesticides, while proposing general fragmentation rules. Information about the fragmentation of drugs and pesticides in the scientific literature is both very scattered and rather incomplete. This book provides comprehensive information on fragmentation pathways of the various chemical compound classes. Whenever available or useful, fragmentation in both positive-ion and negative-ion modes is discussed and compared. Interpretation of MS-MS spectra of important classes of compounds including drugs for cardiovascular diseases and hypertension, psychotropic or psychoactive compounds, drugs related to the gastrointestinal tract, antimicrobial compounds, and other classes of drugs, such as steroids, drugs of abuse, as well as pesticides and herbicides ; A general discussion on the fragmentation of even-electron ions in both positive-ion and negative-ion modes ; Important information on how to interpret spectra so that fragments that are not contained in a particular database can be correctly identified ; Discussion on interpretation strategies in different application areas of small-molecule LC-MS ; Introduction to MS-MS technology, concepts, and terminology used in mass spectral analysis ; As there is no comprehensive book on the interpretation of MS-MS mass spectra of small organic molecules, this book would of great interest to many scientists looking to interpret mass spectra of such compounds.

Über diese Auflage

• Verlag: Wiley
• Erscheinungsdatum: 2017
• ISBN 10: 1118500180
• ISBN 13: 9781118500187
• Einband: Tapa dura
• Anzahl der Seiten: 412