This historic book may have numerous typos and missing text. Purchasers can usually download a free scanned copy of the original book (without typos) from the publisher. Not indexed. Not illustrated. 1910 edition. Excerpt: ...The latter are frequently distributed around the periphery. The bacilli infecting such a large muliinuclear giant cell are generally found in the protoplasm at some distance from the nuclei. The protoplasm of the giant cell early shows evidences of necrobiosis or coagulation necrosis or.granular degeneration. While such giant cells are forming the epithelioid cells increase in number. Among them, and particularly around them at some distance from the point where the bacilli are most numerous, small round cells with round, granular, deeply staining nuclei and small protoplasmic bodies appear. These cells are proliferated young connective-tissue cells, which have, however, not attained the larger size and the other characteristics of the epithelioid cells. These are called lymphoid cells. While all these newly formed cells appear and accumulate, they push aside to a great extent the fibrous matrix of the connective tissue in which they have developed. In consequence of this the young cellular tubercle shows a rather scanty fibrous reticulum. If, however, the cell proliferation has remained within moderate limits, when few tubercle bacilli have been present and when they are, perhaps, of a low type of virulency, or when the process has come to a standstill, or when, in consequence of natural or artificial protective influences, a process of healing is setting in, and when some of the newly formed inflammatory cells have disappeared in consequence of softening, liquefaction and absorption, the fibrous reticulum may become quite abundant, particularly at the periphery. During the formation of the tubercular inflammatory granulation tissue, in other words, the tubercle, there is a complete lack of the formation of bloodvessels in the newlv...
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