Signal Transduction by Reactive Oxygen and Nitrogen Species: Pathways and Chemical Principles - Hardcover

Hardcover

ISBN 10: 1402011172 ISBN 13: 9781402011177

Verlag: Springer, 2003

Über diesen Titel

Reseña del editor:

Henry Jay Forman, Jon Fukuto and Martine Torres "Research is to see what everybody else has seen and to think what nobody else has thought. " -- Albert Szent-Gyorgyi Several years ago, one of us put together a book that dealt with various aspects of oxidative stress and introduced the concept of signal transduction by oxidants. Since then, the interest in the mechanisms by which reactive oxygen and nitrogen species (ROS/RNS) can modulate the cell’s response has tremendously grown, paralleling the intense efforts towards identifying new signaling pathways in which phosphorylation/dephosphorylation events take center stage. Evidence is now mounting that production of these species by the cells is required for their function from growth to apoptosis and numerous signaling pathways have been identified where the participation of ROS and RNS is apparent (see Chapters 11-14, 16 and 18). Thus, the field is no more limited to the group of free radical aficionados who have pioneered this area of research but has now gone mainstream. While it is satisfactory for those of us who have been working on this topic for a long time, it has the risk of becoming the “fashionable” motto where those molecules, still mysterious to some, become responsible for everything and anything.

Reseña del editor:

This exciting area of research will benefit from the pulling together of the work from hard-core chemists and free radical aficionados along with that of signaling enthusiasts and cell biologist devotees. This was the idea behind the conception of this new book. Signal Transduction by Reactive Oxygen and Nitrogen Species: Pathways and Chemical Principles provides relevant chemistry that can be applied across signaling systems and summarizes the current state of knowledge in the area of redox signaling, including controversies when they exist and future directions.

ROS and RNS have been implicated in inflammation, aging and cancer and their novel role in signal transduction may offer new clues to their participation in these processes. This volume should be of great interest to researchers involved in a large range of scientific fields from biochemistry and physiology to pharmacology.

Über diese Auflage

• Verlag: Springer
• Erscheinungsdatum: 2003
• ISBN 10: 1402011172
• ISBN 13: 9781402011177
• Einband: Tapa dura
• Anzahl der Seiten: 436
• Herausgeber: Forman Henry, Fukuto J.M., Torres M.