Bioactive Compounds from Natural Sources: Natural Products as Lead Compounds in Drug Discovery - Hardcover

Hardcover

ISBN 10: 1439822298 ISBN 13: 9781439822296

Verlag: CRC Press, 2011

Inhaltsangabe

The first edition of Bioactive Compounds from Natural Sources was published in a period of renewed attention to biologically active compounds of natural origin. This trend has continued and intensified—natural products are again under the spotlight, in particular for their possible pharmacological applications. Largely focusing on natural products as lead compounds in drug discovery, Bioactive Compounds from Natural Sources, Second Edition: Natural Products as Lead Compounds in Drug Discovery is actually a completely new volume containing surveys of selected recent advances in an interdisciplinary area covering chemistry of natural products, medicinal chemistry, biochemistry, and other related topics.

Written by some of the most reputed scientists in the field, this second edition includes new chapters from authors who contributed to the first edition as well as many chapters compiled by new authors. Introducing the reader to strategies and methods in the search for bioactive natural products, this book covers topics including:

• Natural sources of bioactive compounds such as aquatic cyanobacteria, filamentous fungi, and tropical plants,
• The tremendous potentiality of metabolic engineering of natural products biosynthesis
• The contribution of emerging or developing technologies to the study of bioactive natural compounds, namely computational methods and circular dichroism
• The potential of natural or natural-derived compounds for specific therapeutic applications: treatment of viral diseases, regulation of hypoxia-inducible factor, antimalarials, modulation of angiogenesis, and antitumor and wound-healing activity
• Selected examples of natural product families and related synthetic analogues, namely polyphenols and campthotecins

Compiled for researchers and Ph.D. students working in interdisciplinary fields, this book will also be appreciated by readers without a background in chemistry interested in bioactive natural products, their biological and pharmacological properties, and their possible use as chemopreventive or chemotherapeutic agents. Conversely, the biological and pharmacological data and methods are accessible by chemists.

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Über die Autorin bzw. den Autor

Professor Corrado Tringali obtained his BA in chemistry at the University of Catania, Italy, in 1973. From 1977 to 1985 he was an assistant professor, teaching courses in organic chemistry and physical methods in organic chemistry. In November 1985 he became an associate professor (organic chemistry), and since November 2001 he has been a full professor (teaching courses in organic chemistry, natural products chemistry, and physical methods in organic chemistry). At present, he is coordinator of the international Doctorate of Research in Chemical Science program at the University of Catania (Cycles XXII –XIV).

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This book focuses on the modern approach to the isolation of biologically active natural products and provides numerous examples of the isolation and characterization of secondary metabolites. It emphasizes the synthetic or semi-synthetic analogues of natural products, relevant to those working on biomedical applications of natural products. It includes chapters on general methods together with more specific chapters discussing the main topics in the field, including important families or properties of bioactive natural products, synthesis of analogues, biological evaluation of both natural and synthetic products, and structure-activity relationship studies.

Details zur Ausgabe

• Verlag: CRC Press
• Erscheinungsdatum: 2011
• Sprache: Englisch
• ISBN 10: 1439822298
• ISBN 13: 9781439822296
• Einband: Gebundene Ausgabe
• Auflage: 2
• Anzahl der Seiten: 622
• Herausgeber: Tringali Corrado
• Kontakt zum Hersteller: Nicht verfügbar
• Verantwortliche Person: GPSR Kontakt; gpsr@libri.de; ; Europaallee 1; Bad Hersfeld; 36244; Deutschland