Toxin-Induced Models of Neurological Disorders - Softcover

 
9781489914491: Toxin-Induced Models of Neurological Disorders
Softcover
ISBN 10: 1489914498 ISBN 13: 9781489914491
Verlag: Springer, 2013

Inhaltsangabe

Tbis volume discusses and evaluates the use of neurotoxins to produce animal models of human neurodegenerative diseases. Tbe models presented use neuro­ toxins to induce some or most of the pathophysiological changes (including behavioral) that characterize the most studied motor neuron disorders and cogni­ tive disorders (dementia) in humans. Within the biomedical research community, there is little doubt about the utility of such models. But with increasing frequen­ cy, individuals concemed with animal rights question the validity of such models and argue that they actually produce no useful information for understanding or developing treatments for human disorders. Each of the chapters will address this issue, considering the utility, validity, generalizability, and limitations of the models presented. Chapter 1 begins with a brief review of the ethics of animal use in neuro­ biological research, inc1uding a discussion of the criteria that may be used to evaluate animal models of human disease and extrapolate from the model to appropriate questions regarding humans. The limitations of such extrapolation are also discussed, with special consideration of issues specific to the use of neurotoxins. Chapter 2 extends this theme with further consideration of issues and strategies involved in developing neurotoxin-induced models of neuro­ degenerative disorders and assessing risk factors associated with neurotoxin ex­ posure. It then narrows to evaluate the use of a model systems approach to explore neurotoxin-induced leaming and memory deficits in animals as related to humans with dementia.

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Reseña del editor

Tbis volume discusses and evaluates the use of neurotoxins to produce animal models of human neurodegenerative diseases. Tbe models presented use neuro­ toxins to induce some or most of the pathophysiological changes (including behavioral) that characterize the most studied motor neuron disorders and cogni­ tive disorders (dementia) in humans. Within the biomedical research community, there is little doubt about the utility of such models. But with increasing frequen­ cy, individuals concemed with animal rights question the validity of such models and argue that they actually produce no useful information for understanding or developing treatments for human disorders. Each of the chapters will address this issue, considering the utility, validity, generalizability, and limitations of the models presented. Chapter 1 begins with a brief review of the ethics of animal use in neuro­ biological research, inc1uding a discussion of the criteria that may be used to evaluate animal models of human disease and extrapolate from the model to appropriate questions regarding humans. The limitations of such extrapolation are also discussed, with special consideration of issues specific to the use of neurotoxins. Chapter 2 extends this theme with further consideration of issues and strategies involved in developing neurotoxin-induced models of neuro­ degenerative disorders and assessing risk factors associated with neurotoxin ex­ posure. It then narrows to evaluate the use of a model systems approach to explore neurotoxin-induced leaming and memory deficits in animals as related to humans with dementia.

Reseña del editor

This is the first evaluative discussion of the use of neurotoxins to produce animal models of Alzheimer's, Parkinson's, Huntington's and other human neurodegenerative diseases. The work also responds to criticisms of the use of animals in biomedical research by examining the utility, validity, and limitations of the models presented. An excellent resource for researchers and students in the neurosciences and environmental toxicology interested in both the practical and ethical aspects of animal research.

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Verlag
Springer
Erscheinungsdatum
2013
Sprache
Englisch
ISBN 10 
1489914498
ISBN 13 
9781489914491
Einband
Tapa blanda
Anzahl der Seiten
368
Herausgeber
Nonneman A.J., Woodruff M.L.
Kontakt zum Hersteller
Nicht verfügbar
Verantwortliche Person
CMN Printpool Inh. Mathis Neumann
https://www.also.com/ec/cms5/en_6000/6000/index.jsp

Friedrich-Karl-Str. 9
Hamburg
Deutschland

Weitere beliebte Ausgaben desselben Titels

9780306446146: Toxin-Induced Models of Neurological Disorders (Languages and Information Systems)

Vorgestellte Ausgabe

ISBN 10:  0306446146 ISBN 13:  9780306446146
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Hardcover