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Trinucleotide Repeats: Methods and Protocols (Methods in Molecular Biology, 2056, Band 2056) - Hardcover

 
9781493997831: Trinucleotide Repeats: Methods and Protocols (Methods in Molecular Biology, 2056, Band 2056)
Hardcover
ISBN 10: 1493997831 ISBN 13: 9781493997831
Verlag: Humana, 2019

Inhaltsangabe

This detailed book contains techniques to explore the unusual properties of the peculiar microsatellites known as trinucleotide repeats.  Beginning with technical challenges raised by secondary structure-forming repeats and their propensity to contract and expand over time, the book continues with genetic screens in Saccharomyces cerevisiae, experimental systems to study trinucleotide repeat instability in human cells, dedicated experimental systems in appropriate cell types, as well as gene therapy approaches using the CRISPR-Cas family of endonucleases.  Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. 


Authoritative and practical, Trinucleotide Repeats: Methods and Protocols serves as avaluable aid to experts and newcomers alike who seek to investigate this fascinating and ever-expanding field of study.

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This detailed book contains techniques to explore the unusual properties of the peculiar microsatellites known as trinucleotide repeats.  Beginning with technical challenges raised by secondary structure-forming repeats and their propensity to contract and expand over time, the book continues with genetic screens in Saccharomyces cerevisiae, experimental systems to study trinucleotide repeat instability in human cells, dedicated experimental systems in appropriate cell types, as well as gene therapy approaches using the CRISPR-Cas family of endonucleases.  Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. 


Authoritative and practical, Trinucleotide Repeats: Methods and Protocols serves as avaluable aid to experts and newcomers alike who seek to investigate this fascinating and ever-expanding field of study.

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Verlag
Humana
Erscheinungsdatum
2019
Sprache
Englisch
ISBN 10 
1493997831
ISBN 13 
9781493997831
Einband
Gebundene Ausgabe
Auflage
1
Anzahl der Seiten
297
Herausgeber
Richard Guy-Franck
Kontakt zum Hersteller
preigu GmbH & Co. KG
mail@preigu.de

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