A state-of-the-art examination of research in this field and the impact of this gram-positive pathogen on human disease. Provides coverage of topics in basic microbiology such as details of DNA transformation, molecular and medical epidemiology, the molecular basis of invasive disease, and various interactions with host defenses. Presents important historical information on the field of pneumococcal research and suggests strategies for future investigation. Serves as a valuable source of information for graduate and medical school students, infectious disease specialists, and field researchers in the pathogenesis of gram-positive bacteria.
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particularly fascinating topics covered in this volume include: comparative gram positive genomics; human and bacterial determinants of colonization versus invasive disease; gram positive interaction with innate immune response; traffic of bacteria through epithelia and endothelia; continuing evolution of antibiotic resistance; building the ultimate vaccine.
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