Toxicogenomics and Proteomics: v. 356 (NATO Science Series: Life & Behavioural Sciences) - Hardcover

9781586034023: Toxicogenomics and Proteomics: v. 356 (NATO Science Series: Life & Behavioural Sciences)

Hardcover

ISBN 10: 1586034022 ISBN 13: 9781586034023

Verlag: IOS Press,US, 2006

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Toxicology uses a variety of models to assess the behavioral and histopathological consequences of exposure to certain chemicals, primarily those described here as "environmental insults." While useful to some degree, these assessments are not particularly helpful in determining the outcome of low-level exposure, or exposure to several chemicals, and they do not offer sufficient explanations of outcomes on the molecular level. In this collection of 15 papers, contributors describe research in new studies of gene activity which make it possible to develop a predictive toxicology based on analyses of the genome, proteome, and metabolome. The collection includes papers on classic toxicology as well as the new fields of research. Also, because developing nations tend to have the toxicological problems while developed nations tend to have the latest technological developments, the collection includes papers addressing toxicology in public health research. Annotation �2004 Book News, Inc., Portland, OR (booknews.com)

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The field of toxicology has developed a well-characterized set of techniques to assess the behavioral and histopathological consequences of exposure to environmental insults using a number of animal models. These techniques are suitable for determining crude endpoints of exposure such as death, but are not optimal for assessing the more subtle effects of very low level or multi-agent chemical exposures, nor do they offer mechanistic explanations at the molecular level. This book is designed to have a mix of chapters devoted to classical toxicology followed by those focused more on the emerging techniques of toxicogenomics and proteomics. In this way, the relevance of new technologies such as gene arrays to classical toxicologic problems is made evident. Finally, because the worst of the world’s toxicology problems reside in developing nations while the latest technical developments are occurring in the industrial nations, we sought to provide a balance of both scientific and geographical perspectives from researchers engaged in toxicology and public health research.

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The field of toxicology has developed a well-characterized set of techniques to assess the behavioral and histopathological consequences of exposure to environmental insults using a number of animal models. These techniques are suitable for determining crude endpoints of exposure such as death, but are not optimal for assessing the more subtle effects of very low level or multi-agent chemical exposures, nor do they offer mechanistic explanations at the molecular level. This book is designed to have a mix of chapters devoted to classical toxicology followed by those focused more on the emerging techniques of toxicogenomics and proteomics. In this way, the relevance of new technologies such as gene arrays to classical toxicologic problems is made evident. Finally, because the worst of the world's toxicology problems reside in developing nations while the latest technical developments are occurring in the industrial nations, we sought to provide a balance of both scientific and geographical perspectives from researchers engaged in toxicology and public health research.

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