Endoplasmic Reticulum: A Metabolic Compartment (NATO Science Series: Life & Behavioural Sciences) - Hardcover

 
9781586034740: Endoplasmic Reticulum: A Metabolic Compartment (NATO Science Series: Life & Behavioural Sciences)
Hardcover
ISBN 10: 158603474X ISBN 13: 9781586034740
Verlag: IOS Press, 2005

Inhaltsangabe

Benedetti (pathophysiology and experimental medicine, U. of Siena, Italy) et al. assemble 17 essays by an international group of scientists from the NATO Advanced Research Workshop on Endoplasmic Reticulum sponsored by the Certosa di Pontignano at Siena University in 2003. Papers encompass experimental research in the biochemistry and pathophysiology of the endoplasmic reticulum, genetic and metabolic diseases, and new research on its functions such as the glucose-6-phosphatase system, development disorders, regulation, genes and proteins, redox homeostasis and control, metabolism, and oxidative stress. There is an author list, but no subject index. Annotation ©2005 Book News, Inc., Portland, OR (booknews.com)

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Von der hinteren Coverseite

The endoplasmic reticulum is a continuous membrane network in the cytosol, which encloses its internal compartment, the endoplasmic reticulum lumen. Several metabolic pathways are compartmentalised within the ER lumen, for example hydrolysis of glucose 6-phosphate, glucuronidation of endo- xenobiotics, posttranslational modification of proteins including redox reactions required for oxidative folding, oxidoreduction of steroid hormones, synthesis of ascorbate. Therefore, enzyme activities of these pathways depend on the special luminal microenvironment, on access to substrates and on release of products. However, in spite of great efforts, the molecular mechanism for the generation and maintenance of this special microenvironment still remains to be elucidated. Beside the well-known functions of the endoplasmic reticulum, such as calcium signaling and the synthesis of secretory proteins, recent findings underlined the importance of the intraluminal redox biochemistry and the role of membrane transporters. The field is currently undergoing extensive reappraisal, new transporters have been identified either molecular or functional level. The local synthesis and the membrane transport of redox active compounds (pro- and antioxidants) seem to be important not only in the disulfide bond formation, but also in the generation of intracellular proliferative/apoptotic signals. The different points of views in this publication help highlight the potential importance of several recently described phenomena, whose significance needs elucidation.

Aus dem Klappentext

The endoplasmic reticulum is a continuous membrane network in the cytosol, which encloses its internal compartment, the endoplasmic reticulum lumen. Several metabolic pathways are compartmentalised within the ER lumen, for example hydrolysis of glucose 6-phosphate, glucuronidation of endo- xenobiotics, posttranslational modification of proteins including redox reactions required for oxidative folding, oxidoreduction of steroid hormones, synthesis of ascorbate. Therefore, enzyme activities of these pathways depend on the special luminal microenvironment, on access to substrates and on release of products. However, in spite of great efforts, the molecular mechanism for the generation and maintenance of this special microenvironment still remains to be elucidated. Beside the well-known functions of the endoplasmic reticulum, such as calcium signaling and the synthesis of secretory proteins, recent findings underlined the importance of the intraluminal redox biochemistry and the role of membrane transporters. The field is currently undergoing extensive reappraisal, new transporters have been identified either molecular or functional level. The local synthesis and the membrane transport of redox active compounds (pro- and antioxidants) seem to be important not only in the disulfide bond formation, but also in the generation of intracellular proliferative/apoptotic signals. The different points of views in this publication help highlight the potential importance of several recently described phenomena, whose significance needs elucidation.

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Verlag
IOS Press
Erscheinungsdatum
2005
Sprache
Englisch
ISBN 10 
158603474X
ISBN 13 
9781586034740
Einband
Gebundene Ausgabe
Anzahl der Seiten
162
Herausgeber
Benedetti Angelo, Banhegyi Gabor, Burchell Ann
Kontakt zum Hersteller
Nicht verfügbar
Verantwortliche Person
Nicht verfügbar