Proprotein Convertases: Discovery, Characteristics, and Link to Tumor Progression and Metastasis (Colloquium Series on Protein Activation and Cancer) - Softcover

Khatib, Abdel-Majid

Softcover

ISBN 10: 1615045368 ISBN 13: 9781615045365

Verlag: Morgan & Claypool Life Sciences, 2013

Inhaltsangabe

Páginas:86Géneros:12:PSD:MolecularbiologySinopsis:Proproteinconvertases(PCs)areafamilyofproteasesincludingPC1,PC2,Furin,PC4,PACE4,PC5,andPC7.Theseenzymesareinvolvedinthematurationofmanyprecursorproteinsinvolvedintheprocessoftumorigenesisandmetastasis.Sincetheirdiscovery,PCsweresuggestedaspotentialtargetsforanti-cancertherapy,andtheiractivitywasfoundtodirectlyaffecttumorcellproliferation,migrationinvasion,andthemalignantphenotypesoftumorcells.Here,wediscussanumberofpreviousandrecentfindingsonthePCsfeatures,theirimplicationintheregulationofmultiplecellularfunctionsthatimpactontheinvasive/metastaticpotentialofcancercells,andtheirclinicalrelevanceincancerpatients.Amongthesubstratesoftheproproteinconvertases,variousgrowthfactors,theirreceptors,adhesionmolecules,andproteaseswereidentified.ThePCsareinhibitedbyendogenousandexogenousinhibitors.Todate,onlypro7B2,aspecificchaperoneofPC2,andthegranine-likeprecursorofneuroendocrineproteinproSAAS,aselectiveligandofPC1,havebeenidentifiedasendogenousinhibitorsofthePCsfoundintheregulatedpathway.However,onlyPCsprosegments,severalbioengineeredinhibitors,peptides,andnon-peptidecompoundswerefoundtoinhibittheactivityofthePCsfoundinthesecretorypathway._,

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Reseña del editor

Proprotein convertases (PCs) are a family of proteases including PC1, PC2, Furin, PC4, PACE4, PC5, and PC7. These enzymes are involved in the maturation of many precursor proteins involved in the process of tumorigenesis and metastasis. Since their discovery, PCs were suggested as potential targets for anti-cancer therapy, and their activity was found to directly affect tumor cell proliferation, migration invasion, and the malignant phenotypes of tumor cells. Here, we discuss a number of previous and recent findings on the PCs features, their implication in the regulation of multiple cellular functions that impact on the invasive/metastatic potential of cancer cells, and their clinical relevance in cancer patients. Among the substrates of the proprotein convertases, various growth factors, their receptors, adhesion molecules, and proteases were identified. The PCs are inhibited by endogenous and exogenous inhibitors. To date, only pro7B2, a specific chaperone of PC2, and the granine-like precursor of neuroendocrine protein proSAAS, a selective ligand of PC1, have been identified as endogenous inhibitors of the PCs found in the regulated pathway. However, only PCs prosegments, several bioengineered inhibitors, peptides, and non-peptide compounds were found to inhibit the activity of the PCs found in the secretory pathway.

Biografía del autor

University of Bordeaux, France Research Director, INSERM, and, University of Bordeaux

Details zur Ausgabe

• Verlag: Morgan & Claypool Life Sciences
• Erscheinungsdatum: 2013
• ISBN 10: 1615045368
• ISBN 13: 9781615045365
• Einband: Tapa blanda
• Sprache: Englisch
• Anzahl der Seiten: 84