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Processing of Vegf-C and -D by the Proprotein Convertases: Importance in Angiogenesis, Lymphangiogenesis, and Tumorigenesis (Colloquium Series on Protein Activation and Cancer, 6, Band 6) - Softcover

Siegfried, Geraldine; Khatib, Abdel-Majid

 
9781615046102: Processing of Vegf-C and -D by the Proprotein Convertases: Importance in Angiogenesis, Lymphangiogenesis, and Tumorigenesis (Colloquium Series on Protein Activation and Cancer, 6, Band 6)
Softcover
ISBN 10: 1615046100 ISBN 13: 9781615046102
Verlag: Biota Publishing, 2014

Inhaltsangabe

The vascular endothelial growth factor (VEGF) family members that include VEGF-A, -B, -C, -D,and placental growth factor (PlGF), display distinct binding affinities for their receptors VEGFR-1,-2, and/or -3. In addition to their requirements in the initiation, development, and maintenance ofblood and lymphatic vasculature, VEGFs and VEGFRs are upregulated during neoplasia and areinvolved in the remodeling of tumoral blood and lymphatic vasculature. By activating VEGFR-1and VEGFR-2, both expressed on blood endothelial cells, VEGF-A promotes the formation ofnew tumoral blood vessels and thereby accelerates tumor growth. In contrast, upregulation ofVEGF-C, a ligand for lymphatic endothelial VEGFR-3 as well as for VEGFR-2, induces theformation of tumor-associated lymphatic vessels and thus promotes the passive metastatic disseminationof tumor cells to regional lymph nodes. Of the VEGF family members, only VEGF-C and-D were found to be proteolytically processed by Furin-like enzymes. This processing controlsthe selective activation of VEGFR-2 and -3 signaling during tumor angiogenesis and lymphangiogenesis.Here, we provide an overview of angiogenesis processes and discuss the importance ofVEGF-C and VEGF-D precursors processing by the proprotein convertases during the activationof VEGFR-2 and VEGFR-3 receptors and the mediation of their functions during angiogenesis,lymphangiogenesis, and tumorigenesis.

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Über die Autorin bzw. den Autor

University of Bordeaux, LAMC, UMR 1029, F-3400 and INSERM U1029, France

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Verlag
Biota Publishing
Erscheinungsdatum
2014
Sprache
Englisch
ISBN 10 
1615046100
ISBN 13 
9781615046102
Einband
Taschenbuch
Anzahl der Seiten
66
Kontakt zum Hersteller
Nicht verfügbar
Verantwortliche Person
preigu
mail@preigu.de

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