Optimization in Drug Discovery: In Vitro Methods (Methods in Pharmacology and Toxicology) - Hardcover

 
9781627037419: Optimization in Drug Discovery: In Vitro Methods (Methods in Pharmacology and Toxicology)
Hardcover
ISBN 10: 1627037411 ISBN 13: 9781627037419
Verlag: Humana, 2013

Inhaltsangabe

Thoroughly revised and updated, Optimization in Drug Discovery: In Vitro Methods, Second Edition presents a wide spectrum of in vitro assays including formulation, plasma binding, absorption and permeability, cytochrome P450 (CYP) and UDP-glucuronosyltransferases (UGT) metabolism, CYP inhibition and induction, drug transporters, drug-drug interactions via assessment of reactive metabolites, genotoxicity, and chemical and photo-mutagenicity assays. Written for the Methods in Pharmacology and Toxicology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and tips on troubleshooting and avoiding known pitfalls. Expert authors have developed and utilized these in vitro assays to achieve “drug-like” characteristics in addition to efficacy properties and good safety profiles of drug candidates.

Comprehensive and up-to-date, Optimization in Drug Discovery: In Vitro Methods, Second Edition aims to guide researchers down the difficult path to successful drug discovery and development.

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Von der hinteren Coverseite

Thoroughly revised and updated, Optimization in Drug Discovery: In Vitro Methods, Second Edition presents a wide spectrum of in vitro assays including formulation, plasma binding, absorption and permeability, cytochrome P450 (CYP) and UDP-glucuronosyltransferases (UGT) metabolism, CYP inhibition and induction, drug transporters, drug-drug interactions via assessment of reactive metabolites, genotoxicity, and chemical and photo-mutagenicity assays. Written for the Methods in Pharmacology and Toxicology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and tips on troubleshooting and avoiding known pitfalls. Expert authors have developed and utilized these in vitro assays to achieve “drug-like” characteristics in addition to efficacy properties and good safety profiles of drug candidates.

Comprehensive and up-to-date, Optimization in Drug Discovery: In Vitro Methods, Second Edition aims to guide researchers down the difficult path to successful drug discovery and development.

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Verlag
Humana
Erscheinungsdatum
2013
Sprache
Englisch
ISBN 10 
1627037411
ISBN 13 
9781627037419
Einband
Gebundene Ausgabe
Auflage
2
Anzahl der Seiten
614
Herausgeber
Caldwell Gary W., Yan Zhengyin
Kontakt zum Hersteller
preigu GmbH & Co. KG
mail@preigu.de

Lengericher Landstr. 19
Osnabrück
Niedersachsen
49078
Deutschland

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9781493960705: Optimization in Drug Discovery: In Vitro Methods (Methods in Pharmacology and Toxicology)

Vorgestellte Ausgabe

ISBN 10:  1493960709 ISBN 13:  9781493960705
Verlag: Humana, 2016
Softcover