The field of epigenetics is revolutionizing our understanding of how environment shapes our genes. Dr. Susan Prescott is a leading childhood immunologist who shows how the application of epigenetics through Developmental Origins of Health and Disease (DOHaD) is changing scientific research and public health. A poor start to life is associated with an increased risk of disorders throughout life, including cardiovascular disease, obesity, type 2 diabetes and metabolic disturbances, osteoporosis, chronic obstructive lung disease, some forms of cancer, and some mental illnesses. The environment in which early life develops - at conception, and/or during fetal life, infancy, and early childhood - induces changes in development that have a long term impact on later health and disease risk. Parental lifestyle, diet, smoking, obesity, as well as exposure to endocrine disruptor chemicals and toxins, have all been shown to modulate disease risk. The effects of such exposures are often graded and subtle - they do not simply disrupt development or induce disease themselves - but can affect how rapidly disease develops in an individual. However, timely interventions may reduce such risk in individuals and also limit its transmission to the next generation. DOHaD has significant implications for many societies and for global health policy. Therefore, in this book, Dr. Prescott explains the research and shows how a focus on early life - in health promotion, the exchange of knowledge between policymakers, clinical and basic scientists and the wider public, and education and training - will build capacity to assist a healthy start to life across populations. [Subject: Health, Medicine, Pediatrics, Biology, Public Policy]
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Soft cover. Zustand: Very Good. 1st Edition. Very good condition. Minor wear to book corners and edges. Interior and binding are still excellent. Prevention is the ultimate approach to reducing the burden of all kinds of disease, and the greatest potential for success lies in early life. What happens during early critical periods of life can determine our longevity and our risk of disease decades later. In other words, how well we start life will determine how well we finish it. Dr Susan Prescott, a pediatrician internationally recognised for her work in disease prevention through healthier lifestyles, takes us on a journey of health, beginning from the first moments of life, revealing how adverse conditions during the important stages of our development can have a far more profound effect on our body structures, functions and even our developing behaviours. She draws on the latest research to explain how early life conditions determine our biological reserve, our capacity to deal with life's challenges, and how many of the consequences may not appear until much later in life. Covering a broad range of topics including obesity, diabetes, heart disease, cancer, allergy, arthritis and mental health, she shows how improving conditions in early life is critical for long-term health and longevity, and in the prevention of adverse conditions. Bestandsnummer des Verkäufers 00665
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