Bio-Inspired Polymers (RSC Polymer Chemistry) (Polymer Chemistry, 22, Band 22) - Hardcover

Hardcover

ISBN 10: 1782624139 ISBN 13: 9781782624134

Verlag: RSC Polymer Chemistry, 2016

Inhaltsangabe

Many key aspects of life are based on naturally occurring polymers, such as polysaccharides, proteins and DNA. Unsurprisingly, their molecular functionalities, macromolecular structures and material properties are providing inspiration for designing new polymeric materials with specific functions, for example, responsive, adaptive and self-healing materials.

Bio-inspired Polymers covers all aspects of the subject, ranging from the synthesis of novel polymers, to structure-property relationships, materials with advanced properties and applications of bio-inspired polymers in such diverse fields as drug delivery, tissue engineering, optical materials and lightweight structural materials.

Written and edited by leading experts on the topic, the book provides a comprehensive review and essential graduate level text on bio-inspired polymers for biochemists, materials scientists and chemists working in both industry and academia.

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Von der hinteren Coverseite

Many key aspects of life are based on naturally occurring polymers, such as polysaccharides, proteins, and DNA. Unsurprisingly, their molecular functionalities, macromolecular structures and material properties are providing inspiration for designing new polymeric materials with specific functions for example responsive, adaptive and self-healing materials.

Bio-inspired Polymers covers all aspects of the subject, ranging from the synthesis of novel polymers, to structure-property relationships, materials with advanced properties and applications of bio-inspired polymers in such diverse fields as drug delivery, tissue engineering, optical materials and lightweight structural materials.

Written and edited by leading experts on the topic, the book provides a comprehensive review and essential graduate level text on bio-inspired polymers for biochemists, materials scientists and polymer chemists working in both industry and academia.

Aus dem Klappentext

Many key aspects of life are based on naturally occurring polymers, such as polysaccharides, proteins, and DNA. Unsurprisingly, their molecular functionalities, macromolecular structures and material properties are providing inspiration for designing new polymeric materials with specific functions for example responsive, adaptive and self-healing materials.

Bio-inspired Polymers covers all aspects of the subject, ranging from the synthesis of novel polymers, to structure-property relationships, materials with advanced properties and applications of bio-inspired polymers in such diverse fields as drug delivery, tissue engineering, optical materials and lightweight structural materials.

Written and edited by leading experts on the topic, the book provides a comprehensive review and essential graduate level text on bio-inspired polymers for biochemists, materials scientists and polymer chemists working in both industry and academia.

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Bio-inspired Polymers

By Nico Bruns, Andreas F. M. Kilbinger

The Royal Society of Chemistry

Copyright © 2017 The Royal Society of Chemistry
All rights reserved.

ISBN: 978-1-78262-413-4

Contents

Chapter 1 Synthetic Aspects of Peptide- and Protein-Polymer Conjugates in the Post-click Era Maria Meißler, Sebastian Wieczorek, Niels ten Brummelhuis and Hans G. Börner, 1, 
Chapter 2 Glycopolymers Laura Hartmann and Kira Neuhaus, 31, 
Chapter 3 Synthesis of Non-natural Polymers with Controlled Primary Structures Abdelaziz Al Ouahabi, Raj Kumar Roy and Jean-Francois Lutz, 66, 
Chapter 4 Single-chain Nanoparticles Justin P. Cole, Christopher K. Lyon and Erik B. Berda, 107, 
Chapter 5 Polymeric Tubular Structures Samantha Doninelli, Michael Badoux and Andreas F. M. Kilbinger, 141, 
Chapter 6 Bio-inspired Polymer Membranes Viktoria Mikhalevich, Christina Zelmer, Anja Car, Cornelia Palivan and Wolfgang Meier, 221, 
Chapter 7 Polymeric Ionic Liquids with Micelle-like Topologies and Functions Benjamin Kerscher, Fabian Schüler, AnnaKatharina Evers and Rolf Mülhaupt, 259, 
Chapter 8 Biological and Bio-inspired Heterogeneous Composites: From Resilient Palm Trees to Stretchable Electronics Markus Riiggeberg, Andre R. Studart and Ingo Burgert, 286, 
Chapter 9 Translating Mussel Adhesion: Four Uncertainties about the Interface J. Herbert Waite, 305, 
Chapter 10 Mussel Adhesive-inspired Polymers Bruce P. Lee, 322, 
Chapter 11 Self-reporting Polymeric Materials with Mechanochromic Properties Jose V. Araujo, Omar Rifaie-Graham, Edward A. Apebende and Nico Bruns, 354, 
Chapter 12 Mechanically Adaptive Nanocomposites Inspired by Sea Cucumbers Dafni Moatsou and Christoph Weder, 402, 
Chapter 13 Bio-inspired Polymer Artificial Muscles Sina Naficy, Geoffrey M. Spinks and Ray H. Baughman, 429, 
Chapter 14 Materials for Tissue Engineering and 3D Cell Culture Caitlin R. Langford and Neil R. Cameron, 460, 
Chapter 15 Antimicrobial Polymers and Surfaces – Natural Mimics or Surpassing Nature? Christian Krumm and Joerg C. Tiller, 490, 
Chapter 16 Superwettability of Polymer Surfaces Xi Yao, Jie Ju and Lei Jiang, 523, 
Chapter 17 Bio-mimetic Structural Colour using Biopolymers Rox Middleton, Ullrich Steiner and Silvia Vignolini, 555, 
Subject Index, 586, 

CHAPTER 1

Synthetic Aspects of Peptide – and Protein – Polymer Conjugates in the Post-click Era

MARIA MEIßLER, SEBASTIAN WIECZOREK, NIELS TEN BRUMMELHUIS AND HANS G. BÖRNER

1.1 Introduction

The synthesis of peptide- and protein-polymer conjugates offers the possibility to integrate properties of biological macromolecules into synthetic systems, thereby obtaining hybrid materials with unique functions. The synthetic polymers within these structures provide a versatile range of properties, whereas the peptide or protein domain introduces highly specific functions, ranging from enzymatic activity to specific interaction capabilities or recognition, and to disease modifying activities (Figure 1.1). The multidisciplinary field of creating bioconjugates gives access to a variety of materials for application in materials science, biotechnology, or pharmacology, where the bioconjugates act at the interface between biology and synthetic materials.

First attempts to combine synthetic polymers with biomacromolecules emerged in the early 1950s, when initial reports concerning the synthesis of peptide-polymer conjugates were published by Jatzkewitz. About 20 years later, Abuchowski, Davis, and coworkers described the attachment of a linear poly(ethylene oxide) (PEO) to bovine serum albumin (BSA) and bovine liver catalase. Particularly noteworthy was that the extensive modification of these proteins with a synthetic polymer block did not inhibit the functionality of the biological macromolecules while simultaneously reducing their immunogenicity and increasing blood circulation times. This widely used strategy of incorporating PEO onto proteins or peptides with the objective of improving the properties of biomacromolecules is termed "PEGylation", referring to poly(ethylene glycol) or PEG. Due to polymer modification, the stability of the resulting protein-polymer conjugates toward proteolytic digestion and antibody interactions can often be decreased significantly. This enhancement in stability and solubility of the modified proteins represents an important improvement for in vivo applications, such as in pharmaceutical research and the development of protein-based drugs. Ever since these pioneering works showed the potential of PEGylation, and the combination of proteins or peptides with synthetic polymers in general, many research groups have started to investigate peptide-polymer conjugates as a new class of hybrid materials.

Controlled techniques to connect the building blocks from the synthetic and the biological worlds are indispensable for the preparation of well-defined peptide- and protein-polymer conjugates. In 2001, Sharpless, Kolb, and Finn introduced the concept of ("click" chemistry, which describes the most important criteria to attach two molecules to each other in a highly selective and efficient manner. A reaction defined under this term has to result in very high yields and easily isolable products, while generating only non-hazardous side products that can easily be removed afterwards. Besides the copper(I)-catalyzed cycloaddition (CuAAC) between alkynes and azides described independently by Sharpless and Meldal, a wide range of ligation strategies have since been found to fulfill the criteria of "click" reactions. Of these (in addition to CuAAC), the strain-promoted azide-alkyne cycloaddition (SPAAC), Staudinger ligation, oxime formation, Michael-type additions and other thiol-ene reactions are among the most frequently cited representatives. The advent of various highly efficient reactions has also proved advantageous for the preparation of peptide – and protein-polymer conjugates; these synthetic strategies offer versatile opportunities in the fields of materials science and biomedicine, where they are being applied widely.

In conjunction with the emerging "click" reactions in this century, scientists have focused on the development of innovative strategies to design more complex structures. The rich world of chemical ligation tools, which have traditionally been used for protein modification, has extensively been reviewed. This book chapter will mainly provide an overview of the last decade's progress over the preparation of functional bioconjugates, also referred to as "post-click" methods. After a brief survey of various well-established and widely used ligation techniques, we will focus on novel types of chemistry as well as chemoenzymatic approaches and biotransformations to create functional bioconjugates using enzymatically catalyzed reactions. Finally, recent advances in this field will be described to provide insight into potential future directions for the preparation of functional peptide- and protein-polymer conjugates.

1.2 General Concepts for Bioconjugation

The most widely used method to prepare bioconjugates is based on a convergent strategy – the so-called "grafting to" approach (Figure 1.2a). In order to obtain well-defined structures, the peptide or protein, which contains one or more reactive groups, is reacted with a polymer bearing complementary reactive groups. The "grafting to" approach is applied most since the independent...

Details zur Ausgabe

• Verlag: RSC Polymer Chemistry
• Erscheinungsdatum: 2016
• Sprache: Englisch
• ISBN 10: 1782624139
• ISBN 13: 9781782624134
• Einband: Gebundene Ausgabe
• Anzahl der Seiten: 612
• Herausgeber: Bruns Nico, Kilbinger Andreas F. M.
• Kontakt zum Hersteller: Nicht verfügbar
• Verantwortliche Person: preigu; mail@preigu.de; ; Lengericher Landstr. 19; Osnabrück; 49078; Deutschland