Smart Materials for Tissue Engineering: Applications (Smart Materials, 25) - Hardcover

Hardcover

ISBN 10: 1782624848 ISBN 13: 9781782624844

Verlag: Royal Society of Chemistry, 2017

Inhaltsangabe

In the last couple of decades, research in the area of tissue engineering has witnessed tremendous progress. Research has been aimed towards replacing or facilitating the regeneration of damaged or diseased cell, tissue or organs by applying a biomaterial support system, and a combination of cells and bioactive molecules. Following on from the first volume, Smart Materials for Tissue Engineering: Fundamental Principles, this book comprehensively covers the applications of smart materials providing a valuable resource for biochemists, materials scientists and biomedical engineers working in industry and academia.

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In the last couple of decades, research in the area of tissue engineering has witnessed tremendous progress. The focus has been on replacing or facilitating the regeneration of damaged or diseased cell, tissue or organs by applying a biomaterial support system, and a combination of cells and bioactive molecules. In addition new smart materials have been developed which provide opportunities to fabricate, characterize and utilize materials systematically to control cell behaviours and tissue formation by biomimetic topography that closely replicate the natural extracellular matrix. Following on from Smart Materials for Tissue Engineering: Fundamental Principles, this book comprehensively covers the different uses of smart materials in tissues engineering, providing a valuable resource for biochemists, materials scientists and biomedical engineers working in industry and academia.

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Smart Materials for Tissue Engineering

Applications

By Qun Wang

The Royal Society of Chemistry

Copyright © 2017 The Royal Society of Chemistry
All rights reserved.

ISBN: 978-1-78262-484-4

Contents

Chapter 1 Applications of Smart Multifunctional Tissue Engineering Scaffolds M. Kaliva, M. Chatzinikolaidou and M. Vamvakaki, 1, 
Chapter 2 Translational Smart Materials in Tissue Engineering C. Pineda Molina and S. F. Badylak, 39, 
Chapter 3 Applications of Injectable Smart Materials in Tissue Engineering Qiang Zhao, 67, 
Chapter 4 Advances in Silicon Smart Materials for Tissue Engineering Nelli K. Bodiford and Jeffery L. Coffer, 90, 
Chapter 5 Applications of Conductive Materials for Tissue Engineering L. Wang, X. Li, Y H. Tsou and X. Y Xu, 110, 
Chapter 6 Smart Biomaterials for Cell Encapsulation Hui Zhu and Zhiqiang Cao, 144, 
Chapter 7 Multi-Functional Biomaterials for Bone Tissue Engineering Christian Wiraja, Mark S. K. Chong, Yanwan Liao, Sharon W. T. Chew and Chenjie Xu, 169, 
Chapter 8 Smart Biomaterials for Tissue Engineering of Cartilage Mina D. Fahmy, Brinda Shah, Mehdi Razavi, Hossein Jazayeri, Farahnaz Fahimipour, Joshua White, Radi Masri and Lobat Tayebi, 194, 
Chapter 9 Smart Biomaterials for Cardiovascular Tissue Engineering Shinka Miyamoto, Toshihiro Shoji, Hideki Miyachi and Toshiharu Shinoka, 230, 
Chapter 10 Advances of Smart Materials for Wound Healing Junjie Deng, Peter Y. Li and Hao Cheng, 258, 
Chapter 11 Applications of Magnetic-Responsive Materials for Cardiovascular Tissue Engineering Lindsay Steele, Gal Margolis, Smadar Cohen and Boris Polyak, 290, 
Chapter 12 Intestinal Tissue Engineering with Intestinal Stem Cells Zahra Davoudi and Qun Wang, 329, 
Chapter 13 Smart Materials and Systems as Artificial Pancreas for Diabetes Treatment Yuqi Zhang, Mengzhe Wang, Jicheng Yu and Zhen Gu, 358, 
Chapter 14 Smart Materials for Nerve Regeneration and Neural Tissue Engineering Metin Uz and Surya K. Mallapragada, 382, 
Chapter 15 Smart Cell Culture for Tissue Engineering Yehudah Pardo and Minglin Ma, 409, 
Chapter 16 Flexible Micro- and Nanoelectronics for Tissue Engineering H. Acarón Ledesma, K. Koehler and B. Tian, 439, 
Chapter 17 Smart Materials to Regulate the Fate of Stem Cells Jiabin Zhang, Hu Zhang andXia Xu, 473, 
Chapter 18 Smart Drug Delivery Systems for Tissue Engineering Muhanad Ali, Fang Yang and John Jansen, 505, 
Chapter 19 Smart Materials for Central Nervous System Cell Delivery and Tissue Engineering Timothy M. O'Shea, Alexander L. Wollenberg, Alexander M. Bernstein, Darren B. Sarte, Timothy J. Deming and Michael V. Sofroniew, 529, 
Chapter 20 Smart Multifunctional Tissue Engineering Scaffolds Qilong Zhao and Min Wang, 558, 
Chapter 21 Applications of Smart Microfluidic Systems in Tissue Engineering Yin Chen, Lu Huang, KangningRen, Xuetao Shi and Hongkai Wu, 596, 
Chapter 22 Smart 3D Printing Materials for Tissue Engineering Shan-hui Hsu, Kun-Che Hung and Cheng-Wei Chen, 615, 
Chapter 23 Smart Materials-Originated Microfluidic Systems for Tissue Engineering Ashlyn T. Young and Michael A. Daniele, 642, 
Subject Index, 671, 

CHAPTER 1

Applications of Smart Multifunctional Tissue Engineering Scaffolds

M. KALIVA, M. CHATZINIK0LAIDOU M. VAMVAKAKI

1.1 Introduction

Tissue engineering is an attractive approach to restore and replace diseased or defective tissue offering an alternative to other clinical methods such as organ replacement. Conventional tissue engineering approaches involve the use of a scaffold mainly as a structural element with defined physicochemical, mechanical and biological properties and appropriate architecture and porosity to support cell metabolism. However, recent approaches in tissue regeneration combine three key elements: a scaffold as a micro-environment to promote cell adhesion for tissue development, an appropriate cell type, and biomolecules and drugs to guide cell response and function. There has been enormous interest lately in the growth of different types of tissues using multifunctional scaffolds that can actively participate in the process to provide the biological signals that guide and direct cell function (proliferation, growth and differentiation). Such scaffolds are derived from novel functional and smart materials that allow tuning of the properties and behavior of the scaffolds and can perform multiple crucial tasks simultaneously i.e. deliver bioactive and pharmaceutical molecules, direct cell growth and differentiation, and control stem cell behavior.

Organic, inorganic and hybrid (organic-inorganic) materials have all been explored in the development of multifunctional scaffolds. Basic material requirements for use in tissue engineering include biocompatibility, histocompatibility, non-toxicity and the ability to engineer an appropriate scaffold with the required functionalities.

Multifunctional scaffolds based on smart materials have been applied in different tissue engineering fields. The most frequently studied areas in the literature include the use of multifunctional scaffolds in bone, cartilage and muscle formation, in cardiovascular and endothelium tissue engineering, in the growth of skin and in neural regeneration. Other applications include their use in dental, corneal and retina tissue engineering as well as in wound healing. This chapter will focus on the most extensively studied tissues of which the understanding and knowledge have matured the most. Although multifunctional materials and stimuli-sensitive nanoparticulate drug delivery systems have also shown great therapeutic potential for various cardiovascular and infectious diseases and cancer, this application will not be discussed here. In the following, the sections are divided based on the respective tissue of interest, for which the material characteristics and the multifunctionality of materials and scaffolds are discussed (Figure 1.1). The potential clinical applications of the multifunctional scaffolds are also considered.

1.2 Applications of Multifunctional Scaffolds in Tissue Engineering

1.2.1 Bone and Cartilage

Bone is a remarkably organized, hierarchical connective and vascularized tissue that provides mechanical support and serves various biological functions. Degenerative diseases, cancer or injury can cause bone defects. Despite the impressive ability of bone to heal spontaneously after trauma or fractures, a significant need still exists to develop strategies that promote the healing of non-spontaneously healed defects as a result of sufficiently large fractures or diseases with poor healing ability (i.e. osteoporosis, cancer). Bone tissue regeneration is a physiological and complex procedure that involves a well-orchestrated participation of various bioactive molecules. Bone extracellular matrix (ECM) comprises different proteins such as collagen fibronectin (FN), osteocalcin (OC), osteopontin (OPN), and bone sialoprotein (BSP). Different bone morphogenetic proteins (BMps) and growth factors, like transforming growth factor-beta (TGF-ß), insulin-like growth factor (IGF), platelet-derived growth factor (PDGF), fibroblast growth factor (FGF), and vascular endothelial growth factor (VEGF), are actively involved in the process of bone regeneration, in a spatiotemporal and concentration-controlled manner. Multifunctional scaffolds, based on smart materials, are capable of promoting new bone formation, and have received particular attention in the field of bone...

Details zur Ausgabe

• Verlag: Royal Society of Chemistry
• Erscheinungsdatum: 2017
• Sprache: Englisch
• ISBN 10: 1782624848
• ISBN 13: 9781782624844
• Einband: Gebundene Ausgabe
• Anzahl der Seiten: 692
• Herausgeber: Wang Qun
• Kontakt zum Hersteller: Nicht verfügbar
• Verantwortliche Person: Nicht verfügbar