The Biological Chemistry of Nickel: Volume 10 (Metallobiology) - Hardcover

Hardcover

ISBN 10: 1782624988 ISBN 13: 9781782624981

Verlag: Royal Society of Chemistry, 2017

Über diesen Titel

Reseña del editor:

Metal ions play key roles in biology. Many are essential for catalysis, for electron transfer and for the fixation, sensing, and metabolism of gases. Others compete with those essential metal ions or have toxic or pharmacological effects. This book is structured around the periodic table and focuses on the control of metal ions in cells. It addresses the molecular aspects of binding, transport and storage that ensure balanced levels of the essential elements. Organisms have also developed mechanisms to deal with the non-essential metal ions. However, through new uses and manufacturing processes, organisms are increasingly exposed to changing levels of both essential and non-essential ions in new chemical forms. They may not have developed defenses against some of these forms (such as nanoparticles). Many diseases such as cancer, diabetes and neurodegeneration are associated with metal ion imbalance. There may be a deficiency of the essential metals, overload of either essential or non-essential metals or perturbation of the overall natural balance. This book is the first to comprehensively survey the molecular nature of the overall natural balance of metal ions in nutrition, toxicology and pharmacology. It is written as an introduction to research for students and researchers in academia and industry and begins with a chapter by Professor R J P Williams FRS.

Contraportada:

Nickel is an essential element in many biochemical processes and there has been significant research into understanding in great depth the role that this transition element plays. This book provides a comprehensive review of the latest findings in nickel biology, covering the function, biochemistry, toxicology and medical applications of nickel systems.

Chapters discuss a range of topics in this field including the coordination chemistry of nickel-containing biomolecules, current theories on nickel-containing enzymes and the transport, storage and transcriptional regulation of nickel in biological systems. Issues such as the key role of nickel in pathogens, nickel toxicity in humans and the potential medical applications are also examined.

Written by internationally leading experts in nickel biology and chemistry research, this book is an essential reference for bioinorganic chemists, biochemists, biologists and medicinal chemists.

Über diese Auflage

• Verlag: Royal Society of Chemistry
• Erscheinungsdatum: 2017
• ISBN 10: 1782624988
• ISBN 13: 9781782624981
• Einband: Tapa dura
• Anzahl der Seiten: 395
• Herausgeber: Zamble Deborah, Rowińska-Żyrek Magdalena, Kozlowski Henryk